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Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.

Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.

http://www.wikidata.org/entity/Q34123096

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Recent advances in engineering polyvalent biological interactions DNA display of glycoconjugates to emulate oligomeric interactions of glycans Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines History of Chemistry in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).DNA-based digital tension probes reveal integrin forces during early cell adhesion.Instructing cells with programmable peptide DNA hybrids.Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.DNA display of PNA-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands Design of peptide affinity ligands for S-protein: a comparison of combinatorial and de novo design strategies.A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular self-assemblies.PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor Synthesis and characterization of gadolinium-Peptidomimetic complex as an αvβ3 integrin targeted MR contrast agent.Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation.Glycopolymer probes of signal transduction Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells.Integrin-generated forces lead to streptavidin-biotin unbinding in cellular adhesions.Multivalency as a chemical organization and action principle.Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.Carbohydrate-PNA and aptamer-PNA conjugates for the spatial screening of lectins and lectin assemblies.Lighting Up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes.Effects of Variations in Ligand Density on Cell Signaling.Emerging trends in enzyme inhibition by multivalent nanoconstructs.Efficient Self-Assembly of Di-, Tri-, Tetra-, and Hexavalent Hosts with Predefined Geometries for the Investigation of Multivalency.Enhanced cell death imaging using multivalent zinc(II)-bis(dipicolylamine) fluorescent probes.Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening.Design, preparation, and selection of DNA-encoded dynamic libraries Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex.Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry.Reversible blocking of antibodies using bivalent peptide–DNA conjugates allows protease-activatable targeting Dynamic Expression of DNA Complexation with Self-assembled Biomolecular Clusters Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds

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P2860

Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.

http://www.wikidata.org/entity/Q34123096

description

2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2012年の論文

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Nature Communications

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Programmable multivalent displ ...... ide nucleic acid nanoscaffolds

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Daniel H Appella

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Deyun Wang

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Ethan A Englund

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Gema Martin-Manso

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Hidetsugu Fujigaki

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Hiroyasu Sakai

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Michael L Pendrak

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Rodolfo Ghirlando

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Stewart R Durell

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P2860

Crystal structure of the extracellular segment of integrin alpha Vbeta3

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

Self-assembly of DNA into nanoscale three-dimensional shapes

Solution structure of a peptide nucleic acid-DNA duplex

UCSF Chimera--a visualization system for exploratory research and analysis

TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly

Ligand: a versatile computerized approach for characterization of ligand-binding systems

Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands

A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis.

Gold nanoparticles for biology and medicine.

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614

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scholarly article

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10.1038/NCOMMS1629

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3

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David D Roberts

Christopher M Micklitsch

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2012-01-10T00:00:00Z

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221737036

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1018368984

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22233624

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3518395

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