Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity
about
20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells.Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cellsMetabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.On the role of skin in the regulation of local and systemic steroidogenic activities.Novel activities of CYP11A1 and their potential physiological significance.Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.Cytochromes p450 and skin cancer: role of local endocrine pathways.Novel vitamin D photoproducts and their precursors in the skin.In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.PTH and Vitamin D.Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength.Design, synthesis, and biological action of 20R-hydroxyvitamin D3.Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.
P2860
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P2860
Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@ast
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@en
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@nl
type
label
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@ast
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@en
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@nl
prefLabel
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@ast
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@en
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@nl
P2093
P2860
P356
P1476
Purified mouse CYP27B1 can hyd ...... as altered biological activity
@en
P2093
Edith K Y Tang
Minh N Nguyen
Zorica Janjetovic
P2860
P304
P356
10.1124/DMD.110.034389
P577
2010-06-16T00:00:00Z