Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication.
about
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomesKaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeats.Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirusLatency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virusKaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomesKaposi's Sarcoma Herpesvirus Genome PersistenceA Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA ProteinsMolecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANACrystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral LatencyDiscovery of selective inhibitors against EBNA1 via high throughput in silico virtual screeningKSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANAIdentification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral ReplicationLANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complexThermodynamics of cooperative DNA recognition at a replication origin and transcription regulatory site.Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes.KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation.HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus.Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.Chromatin organization of gammaherpesvirus latent genomes.KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine.Characterization of the minimal replicator of Kaposi's sarcoma-associated herpesvirus latent origin.Viral latency and its regulation: lessons from the gamma-herpesviruses.Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1.Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus.Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome.The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells.Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirusThe Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistenceAcetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins.SUMO and KSHV ReplicationKaposi's sarcoma-associated herpesvirus-encoded LANA down-regulates IL-22R1 expression through a cis-acting element within the promoter regionKaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells.Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis.Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAMolecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesisRapid and quantitative assessment of KSHV LANA-mediated DNA replication.The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistenceKaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: dual role of replication and transcription activator.
P2860
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P2860
Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Latency-associated nuclear ant ...... to facilitate DNA replication.
@ast
Latency-associated nuclear ant ...... to facilitate DNA replication.
@en
Latency-associated nuclear ant ...... to facilitate DNA replication.
@nl
type
label
Latency-associated nuclear ant ...... to facilitate DNA replication.
@ast
Latency-associated nuclear ant ...... to facilitate DNA replication.
@en
Latency-associated nuclear ant ...... to facilitate DNA replication.
@nl
prefLabel
Latency-associated nuclear ant ...... to facilitate DNA replication.
@ast
Latency-associated nuclear ant ...... to facilitate DNA replication.
@en
Latency-associated nuclear ant ...... to facilitate DNA replication.
@nl
P2860
P356
P1476
Latency-associated nuclear ant ...... to facilitate DNA replication.
@en
P2093
Alexander C Garber
Jianhong Hu
P2860
P304
27401-27411
P356
10.1074/JBC.M203489200
P407
P50
P577
2002-05-15T00:00:00Z