A functional variant in ERAP1 predisposes to multiple sclerosis.
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Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseA multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responsesRole of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.Recognition of self and altered self by T cells in autoimmunity and allergy.Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis.Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines.ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus.The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis.ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.The role of polymorphic ERAP1 in autoinflammatory disease
P2860
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P2860
A functional variant in ERAP1 predisposes to multiple sclerosis.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A functional variant in ERAP1 predisposes to multiple sclerosis.
@ast
A functional variant in ERAP1 predisposes to multiple sclerosis.
@en
A functional variant in ERAP1 predisposes to multiple sclerosis.
@nl
type
label
A functional variant in ERAP1 predisposes to multiple sclerosis.
@ast
A functional variant in ERAP1 predisposes to multiple sclerosis.
@en
A functional variant in ERAP1 predisposes to multiple sclerosis.
@nl
prefLabel
A functional variant in ERAP1 predisposes to multiple sclerosis.
@ast
A functional variant in ERAP1 predisposes to multiple sclerosis.
@en
A functional variant in ERAP1 predisposes to multiple sclerosis.
@nl
P2093
P2860
P50
P1433
P1476
A functional variant in ERAP1 predisposes to multiple sclerosis.
@en
P2093
Andrea Cassinotti
Domenico Caputo
Franca Rosa Guerini
Rachele Cagliani
P2860
P304
P356
10.1371/JOURNAL.PONE.0029931
P407
P50
P577
2012-01-12T00:00:00Z