AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. - Wikidata - wikimedia - TriplyDB

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.

http://www.wikidata.org/entity/Q34135442

about

Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation A new scheme to discover functional associations and regulatory networks of E3 ubiquitin ligases.AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy.LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells.NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo.Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator.Metformin displays in vitro and in vivo antitumor effect against osteosarcoma.Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer.Proliferation and metastatic potential of endometrial cancer cells in response to metformin treatment in a high versus normal glucose environment.AMP-activated protein kinase and energy balance in breast cancer.miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival.FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc Metformin, an old drug, brings a new era to cancer therapy Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma.CAF cellular glycolysis: linking cancer cells with the microenvironment.Metformin and Prostate Cancer: a New Role for an Old Drug.Addressing intra-tumoral heterogeneity and therapy resistance.hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation.AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer.Down-regulation of adenosine monophosphate-activated protein kinase activity: A driver of cancer.Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen.Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death.Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer Degradation of AMPK by a cancer-specific ubiquitin ligase.High expression of PDLIM5 facilitates cell tumorigenesis and migration by maintaining AMPK activation in prostate cancer.ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism.Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.

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P2860

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.

http://www.wikidata.org/entity/Q34135442

description

2014 nî lūn-bûn

@nan

2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@ast

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@en

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@nl

type

label

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@ast

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@en

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@nl

prefLabel

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@ast

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@en

AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@nl

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0008-5472.CAN-14-0135

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Cancer Research

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AMPK reverses the mesenchymal ...... kt-MDM2-Foxo3a signaling axis.

@en

P2093

Charles L Shapiro

http://www.w3.org/2001/XMLSchema#string

Chih-Chien Chou

http://www.w3.org/2001/XMLSchema#string

Ching-Shih Chen

http://www.w3.org/2001/XMLSchema#string

Dasheng Wang

http://www.w3.org/2001/XMLSchema#string

I-Lu Lai

http://www.w3.org/2001/XMLSchema#string

Kuen-Haur Lee

http://www.w3.org/2001/XMLSchema#string

Samuel K Kulp

http://www.w3.org/2001/XMLSchema#string

Xiaokui Mo

http://www.w3.org/2001/XMLSchema#string

P2860

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

The epithelial-mesenchymal transition generates cells with properties of stem cells

The basics of epithelial-mesenchymal transition

AMPK as a potential anticancer target - friend or foe?

Cellular and molecular mechanisms of metformin: an overview

Epithelial-mesenchymal transitions in development and disease

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

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4783-4795

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10.1158/0008-5472.CAN-14-0135

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17

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74

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4155002

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