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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

http://www.wikidata.org/entity/Q34136997

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Pyruvate Kinase M2: A Potential Target for Regulating Inflammation The sweet trap in tumors: aerobic glycolysis and potential targets for therapy Is cancer a metabolic disease?Translational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory Diseases Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.Tumor bioenergetics: an emerging avenue for cancer metabolism targeted therapy Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis Diversity in TAF proteomics: consequences for cellular differentiation and migration.PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.Epidermal growth-factor-induced transcript isoform variation drives mammary cell migration.Protein-tyrosine phosphatase 1B substrates and metabolic regulation Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms.PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma Activators of PKM2 in cancer metabolism.Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.Targeting glucose metabolism for cancer therapy.Cosilencing of PKM-2 and MDR-1 Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer Biological Relevance and Therapeutic Potential of the Hypusine Modification System.Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy Emerging roles of PKM2 in cell metabolism and cancer progression Targeting cancer metabolism.Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention.PKM2 and cancer: The function of PKM2 beyond glycolysis.Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma.EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape.Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation In Vivo GFP Knockdown by Cationic Nanogel-siRNA Polyplexes Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells.

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P2860

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

http://www.wikidata.org/entity/Q34136997

description

2012 nî lūn-bûn

@nan

2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հունվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@en

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

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type

label

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@ast

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@en

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@nl

prefLabel

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@ast

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@en

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

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Journal of Experimental Medicine

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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

@en

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Michael S Goldberg

http://www.w3.org/2001/XMLSchema#string

Phillip A Sharp

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P2860

Identification of small molecule inhibitors of pyruvate kinase M2

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Structure of the guide-strand-containing argonaute silencing complex

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

On the Origin of Cancer Cells

Alternative isoform regulation in human tissue transcriptomes

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

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217-224

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scholarly article

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10.1084/JEM.20111487

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2

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209

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