Inhibition of protein kinase B/Akt. implications for cancer therapy.
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PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating AktThe protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levelsThe ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationEssential function for ErbB3 in breast cancer proliferationCelecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumoursRegulation of Hepatitis B Virus Replication by the Phosphatidylinositol 3-Kinase-Akt Signal Transduction PathwayBinding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeA multi-targeted approach to suppress tumor-promoting inflammationRole of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibitionA novel role for villin in intestinal epithelial cell survival and homeostasisBeauvericin ameliorates experimental colitis by inhibiting activated T cells via downregulation of the PI3K/Akt signaling pathwayAntisense and dominant-negative AKT2 cDNA inhibits glioma cell invasionNa+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cellsInhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrusIntramolecular and intermolecular interactions of protein kinase B define its activation in vivoInsulin-like growth factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt: effect of alcohol.Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.Short-term alcohol administration alters KiSS-1 gene expression in the reproductive hypothalamus of prepubertal female ratsRABEX-5 is upregulated and plays an oncogenic role in gastric cancer development by activating the VEGF signaling pathway.Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway.Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt SignalingInduction of cancer cell death by isoflavone: the role of multiple signaling pathways.Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathwaysAutocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function.Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cellsNew diagnostic and molecular characteristics of malignant mesothelioma.Cellular signaling perturbation by natural products.A carbazole alkaloid deactivates mTOR through the suppression of rictor and that induces apoptosis in lung cancer cells.Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro.Phytoestrogens induce apoptosis through a mitochondria/caspase pathway in human breast cancer cells.Screening and test of CD40 related signal transduction pathway in AGS cells and construction of gene silencing vector.Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo.Aerosol delivery of Akt controls protein translation in the lungs of dual luciferase reporter mice.Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP.Negative feedback regulation of phosphatidylinositol 3-kinase/Akt pathway by over-expressed cyclooxygenase-2 in human epidermal cancer cells.Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway.
P2860
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P2860
Inhibition of protein kinase B/Akt. implications for cancer therapy.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@ast
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@en
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@nl
type
label
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@ast
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@en
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@nl
prefLabel
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@ast
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@en
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@nl
P1476
Inhibition of protein kinase B/Akt. implications for cancer therapy.
@en
P2093
Brian A Hemmings
Michelle M Hill
P304
P356
10.1016/S0163-7258(02)00193-6
P577
2002-02-01T00:00:00Z