Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.
about
HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactionsRab7A is required for efficient production of infectious HIV-1Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6The restriction factors of human immunodeficiency virusAntiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteractionRemodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceMechanism of HIV-1 virion entrapment by tetherinKLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 VariantIntrinsic cellular defenses against human immunodeficiency virusesCounteraction of the multifunctional restriction factor tetherinActivities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion releaseDifferential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.Modulation of HIV-1-host interaction: role of the Vpu accessory proteinAnalysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin.Identification and functional analysis of three isoforms of bovine BST-2A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity.Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.Cloning and characterization of the antiviral activity of feline Tetherin/BST-2Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.Epitope tags beside the N-terminal cytoplasmic tail of human BST-2 alter its intracellular trafficking and HIV-1 restrictionIdentification of alternatively translated Tetherin isoforms with differing antiviral and signaling activitiesCompensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIVVpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail.Vpu binds directly to tetherin and displaces it from nascent virions.Assembly and replication of HIV-1 in T cells with low levels of phosphatidylinositol-(4,5)-bisphosphate.Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-actionEx vivo gene therapy for HIV-1 treatment.Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles.Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogensAssessing ubiquitination of viral proteins: Lessons from flavivirus NS5.Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral AssemblyDrosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.Structural Basis for the Antiviral Activity of BST-2/Tetherin and Its Viral AntagonismSerine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors.Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain.
P2860
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P2860
Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@ast
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@en
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@nl
type
label
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@ast
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@en
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@nl
prefLabel
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@ast
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@en
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@nl
P2093
P2860
P356
P1433
P1476
Serine-threonine ubiquitinatio ...... d virion release by HIV-1 Vpu.
@en
P2093
Andrey A Tokarev
Jason Munguia
John C Guatelli
P2860
P356
10.1128/JVI.01795-10
P407
P577
2010-10-27T00:00:00Z