Combinatorial and computational challenges for biocatalyst design.
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Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapesHigh-throughput thermal scanning: a general, rapid dye-binding thermal shift screen for protein engineeringUse and improvement of microbial redox enzymes for environmental purposesA dual-fluorescence reporter system for high-throughput clone characterization and selection by cell sortingTriplet nucleotide removal at random positions in a target gene: the tolerance of TEM-1 beta-lactamase to an amino acid deletion.Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsMimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activityDe novo designed cyclic-peptide heme complexesDirected Evolution and Structural Characterization of a Simvastatin SynthaseEnhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolutionDiscovery, Molecular Mechanisms, and Industrial Applications of Cold-Active EnzymesIn-frame amber stop codon replacement mutagenesis for the directed evolution of proteins containing non-canonical amino acids: identification of residues open to bio-orthogonal modificationBiology by design: reduction and synthesis of cellular components and behaviourThe prospects of cellulase-producing bacteria for the bioconversion of lignocellulosic biomassMetaBioME: a database to explore commercially useful enzymes in metagenomic datasetsComputational design of receptor and sensor proteins with novel functions.Self-replicating colloidal clustersGeneration of a broad esterolytic subtilisin using combined molecular evolution and periplasmic expression.Library analysis of SCHEMA-guided protein recombination.Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase.Assembly of designed oligonucleotides as an efficient method for gene recombination: a new tool in directed evolution.Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.Screening mutant libraries of fungal laccases in the presence of organic solvents.Directed evolution of Bacillus subtilis lipase A by use of enantiomeric phosphonate inhibitors: crystal structures and phage display selection.The competitor-introduced Ggamma recruitment system, a new approach for screening affinity-enhanced proteins.Peroxidase activity of de novo heme proteins immobilized on electrodes.Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx).A computational framework to empower probabilistic protein designProtein thermostability calculations using alchemical free energy simulationsExperimental library screening demonstrates the successful application of computational protein design to large structural ensemblesExpanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine.New and highly efficient methodology for screening high-yield strains of cytotoxic deacetylmycoepoxydiene (DAM).Synthetic biology.Breaking open a protein barrelStabilizing proteins from sequence statistics: the interplay of conservation and correlation in triosephosphate isomerase stability.Computational design of receptors for an organophosphate surrogate of the nerve agent soman.Combining computational and experimental screening for rapid optimization of protein propertiesChemical complementation: a reaction-independent genetic assay for enzyme catalysis.Directed Evolution: Past, Present and Future.Design of a zinc-finger hydrolase with a synthetic αββ protein.
P2860
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P2860
Combinatorial and computational challenges for biocatalyst design.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Combinatorial and computational challenges for biocatalyst design.
@ast
Combinatorial and computational challenges for biocatalyst design.
@en
Combinatorial and computational challenges for biocatalyst design.
@nl
type
label
Combinatorial and computational challenges for biocatalyst design.
@ast
Combinatorial and computational challenges for biocatalyst design.
@en
Combinatorial and computational challenges for biocatalyst design.
@nl
prefLabel
Combinatorial and computational challenges for biocatalyst design.
@ast
Combinatorial and computational challenges for biocatalyst design.
@en
Combinatorial and computational challenges for biocatalyst design.
@nl
P356
P1433
P1476
Combinatorial and computational challenges for biocatalyst design.
@en
P2093
P2888
P304
P356
10.1038/35051731
P407
P577
2001-01-01T00:00:00Z
P5875
P6179
1051677107