Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).
about
Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet.Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complexPlatelet biogenesis and functions require correct protein O-glycosylationA new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.The organizing principle of the platelet glycoprotein Ib-IX-V complex.The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shearRole of 14-3-3ζ in platelet glycoprotein Ibα-von Willebrand factor interaction-induced signalingThe role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activationA functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complexThe membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways.Novel roles of cAMP/cGMP-dependent signaling in platelets.The control of blood platelets by cAMP signalling.Of von Willebrand factor and platelets.Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3',5'-cyclic adenosine monophosphate-signaling pathway.Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex.A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications.Binding of platelet glycoprotein Ibbeta through the convex surface of leucine-rich repeats domain of glycoprotein IX.The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface.Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.A palmitylated peptide derived from the glycoprotein Ib beta cytoplasmic tail inhibits platelet activation.Protein kinase A determines platelet life span and survival by regulating apoptosis.The transmembrane domain of glycoprotein Ibbeta is critical to efficient expression of glycoprotein Ib-IX complex in the plasma membrane.14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.
P2860
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P2860
Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of glycoprotein Ib- ...... at Ser 166 of glycoprotein Ib
@nl
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@ast
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@en
type
label
Regulation of glycoprotein Ib- ...... at Ser 166 of glycoprotein Ib
@nl
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@ast
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@en
prefLabel
Regulation of glycoprotein Ib- ...... at Ser 166 of glycoprotein Ib
@nl
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@ast
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@en
P2093
P2860
P356
P1476
Regulation of glycoprotein Ib- ...... 166 of glycoprotein Ib(beta).
@en
P2093
Michael C Berndt
Richard J Bodnar
Xiaodong Xi
Xiaoping Du
P2860
P304
47080-47087
P356
10.1074/JBC.M208329200
P407
P577
2002-10-01T00:00:00Z