Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance. - Wikidata - wikimedia - TriplyDB

Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

http://www.wikidata.org/entity/Q34154223

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Opioid receptor trafficking and interaction in nociceptors Opioid receptors: toward separation of analgesic from undesirable effects Kir3 channel signaling complexes: focus on opioid receptor signaling Cell-autonomous regulation of Mu-opioid receptor recycling by substance P.Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice Novel delta opioid receptor agonists with oxazatricyclodecane structure.β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons.Opioid receptor desensitization: mechanisms and its link to tolerance In vivo opioid receptor heteromerization: where do we stand?Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.The delta opioid receptor: an evolving target for the treatment of brain disorders.Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice.Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus.Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development.Effects of the δ opioid receptor agonist SNC80 on pain-related depression of intracranial self-stimulation (ICSS) in rats.Ligand-directed signalling within the opioid receptor family.Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches.Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels.Pharmacological traits of delta opioid receptors: pitfalls or opportunities?Molecular mechanisms of opioid receptor-dependent signaling and behavior.Bradykinin controls pool size of sensory neurons expressing functional δ-opioid receptors Molecular Pharmacology of δ-Opioid Receptors.β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake.Delta opioid receptors in brain function and diseases Learning-related translocation of δ-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses.Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.Regulation of opioid receptor signalling: implications for the development of analgesic tolerance.Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors.Functional selectivity in GPCR heterocomplexes.Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands.

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Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

http://www.wikidata.org/entity/Q34154223

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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Ligand-directed trafficking of ...... hs toward analgesic tolerance.

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Ligand-directed trafficking of ...... hs toward analgesic tolerance.

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Amynah A A Pradhan

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Audrey Matifas

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Brigitte L Kieffer

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Chihiro Nozaki

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Christopher Evans

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Dominique Filliol

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Eric Erbs

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Wendy Walwyn

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P2860

Delta opioid receptor ligands modulate anxiety-like behaviors in the rat

In vivo delta opioid receptor internalization controls behavioral effects of agonists

Modulation of postendocytic sorting of G protein-coupled receptors

Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist

A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80

Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses

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