Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.

Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.

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http://www.wikidata.org/entity/Q34155054

Q34155054

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The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells DNA methylation and histone H3-K9 modifications contribute to MUC17 expression MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells Structure, evolution, and biology of the MUC4 mucin The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)Clinicopathological and prognostic significance of MUC4 expression in cancers: evidence from meta-analysis Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta Unraveling the clonal hierarchy of somatic genomic aberrations.Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5.Muc4/MUC4 functions and regulation in cancer TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer.Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity.Upregulation of MUC4 in cervical squamous cell carcinoma: pathologic significance.Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedb The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2 Genetic variants in MUC4 gene are associated with lung cancer risk in a Chinese population.MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas.Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy.Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma.Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression.Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas.What role do mucins have in the development of laryngeal squamous cell carcinoma? A systematic review.Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor.Mucins and pancreatic cancer.Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases.Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity.Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas.GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin.Promoter CpG methylation in cancer cells contributes to the regulation of MUC4.Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells: role in reversal of contact inhibition.The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3.MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer.MUC4 is increased in high grade intraepithelial neoplasia in Barrett's oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio.

P2860

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P2860

Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.

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http://www.wikidata.org/entity/Q34155054

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2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

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