Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode. - Wikidata - wikimedia - TriplyDB

Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.

Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.

http://www.wikidata.org/entity/Q34157453

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The roles of intramembrane proteases in protozoan parasites Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide Babesia divergensandNeospora caninumapical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion Large Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane Protease Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion.Ectopic expression of a Neospora caninum Kazal type inhibitor triggers developmental defects in Toxoplasma and Plasmodium Structure and mechanism of rhomboid protease Identification and characterization of Eimeria tenella apical membrane antigen-1 (AMA1)ROP18 is a key factor responsible for virulence difference between Toxoplasma gondii and Neospora caninum.Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole.Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.Functional analysis of rhomboid proteases during Toxoplasma invasion.Comparative in-silico genome analysis of Leishmania (Leishmania) donovani: A step towards its species specificity.Protective immunity induced by peptides of AMA1, RON2 and RON4 containing T-and B-cell epitopes via an intranasal route against toxoplasmosis in mice.Quantitative time-course profiling of parasite and host cell proteins in the human malaria parasite Plasmodium falciparum.Expression, Purification, and Biological Characterization of Babesia microti Apical Membrane Antigen 1.Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate.Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.The moving junction, a key portal to host cell invasion by apicomplexan parasites.Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.Glycoproteins and Gal-GalNAc cause Cryptosporidium to switch from an invasive sporozoite to a replicative trophozoite Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.Inside scoop on outside proteins.Invasion factors are coupled to key signalling events leading to the establishment of infection in apicomplexan parasites.The moving junction of apicomplexan parasites: a key structure for invasion.Functional genetics in Apicomplexa: potentials and limits.Intramembrane proteolysis in regulated protein trafficking.Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.Proteases as regulators of pathogenesis: examples from the Apicomplexa.Rhomboid proteases in plants - still in square one?The rhomboid protease family: a decade of progress on function and mechanism.Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.Architectural and thermodynamic principles underlying intramembrane protease function.Entamoeba histolytica rhomboid protease 1 has a role in migration and motility as validated by two independent genetic approaches.Distinct contribution of Toxoplasma gondii rhomboid proteases 4 and 5 to micronemal protein protease 1 activity during invasion.Rhomboid proteases in invasion and replication of Apicomplexa.

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P2860

Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.

http://www.wikidata.org/entity/Q34157453

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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type

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

@en

Intramembrane cleavage of AMA1 ...... nvasive to a replicative mode.

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SCIENCE.1199284

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Intramembrane cleavage of AMA1 ...... invasive to a replicative mode

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Joana M Santos

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Michael J Blackman

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P2860

Molecular identification of a malaria merozoite surface sheddase

Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite

Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii

Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process

Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

The Toxoplasma homolog of Plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels.

Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii.

Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis

A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma.

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473-477

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scholarly article

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10.1126/SCIENCE.1199284

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6016

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331

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Dominique Soldati-Favre

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2010-12-23T00:00:00Z

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49728242

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21205639

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