Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. - Wikidata - wikimedia - TriplyDB

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

http://www.wikidata.org/entity/Q34162206

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Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex Eculizumab for dense deposit disease and C3 glomerulonephritis Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN Overview of C3 Glomerulopathy Atypical haemolytic uraemic syndrome with underlying glomerulopathies. A case series and a review of the literature Update on membranoproliferative GN Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion Complement System Part II: Role in Immunity A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.Dynamics of complement activation in aHUS and how to monitor eculizumab therapy Complement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndrome.Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.Role of the skin biopsy in the diagnosis of atypical hemolytic uremic syndrome.Complement in disease: a defence system turning offensive Anti-complement-factor H-associated glomerulopathies.Complement C1 esterase inhibitor levels linked to infections and contaminated heparin-associated adverse events Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor.Defining the complement biomarker profile of C3 glomerulopathy Dense deposit disease.Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity Regulating complement in the kidney: insights from CFHR5 nephropathy.Association of a novel complement factor H mutation with severe crescentic and necrotizing glomerulonephritis.Eculizumab and recurrent C3 glomerulonephritis Secondary focal and segmental glomerulosclerosis associated with single-nucleotide polymorphisms in the genes encoding complement factor H and C3.Treatment options for C3 glomerulopathy Causes of alternative pathway dysregulation in dense deposit disease.A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H Glomerulonephritis with isolated C3 deposits and monoclonal gammopathy: a fortuitous association?Complement Dysregulation and Disease: Insights from Contemporary Genetics.The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.New classification of membranoproliferative glomerulonephritis: a good start but a long way to go.C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

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P2860

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

http://www.wikidata.org/entity/Q34162206

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Journal of Clinical Investigation

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Human C3 mutation reveals a me ...... ent activation and regulation.

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Agustín Tortajada

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B Paul Morgan

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Claire L Harris

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Eduardo Vazquez-Martul

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Eva Torreira

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Francisco Valdes-Cañedo

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Margarita Lopez-Trascasa

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Meike Heurich

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Oscar Llorca

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Rubén Martínez-Barricarte

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P2860

Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation

Complement. First of two parts

Complement. Second of two parts

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3702-3712

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10.1172/JCI43343

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10

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120

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Santiago Rodriguez de Córdoba

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2010-09-13T00:00:00Z

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20852386

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