Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.
about
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complexEculizumab for dense deposit disease and C3 glomerulonephritisReclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GNOverview of C3 GlomerulopathyAtypical haemolytic uraemic syndrome with underlying glomerulopathies. A case series and a review of the literatureUpdate on membranoproliferative GNMembranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusionComplement System Part II: Role in ImmunityA humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factorsDisease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.Dynamics of complement activation in aHUS and how to monitor eculizumab therapyComplement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndrome.Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.Role of the skin biopsy in the diagnosis of atypical hemolytic uremic syndrome.Complement in disease: a defence system turning offensiveAnti-complement-factor H-associated glomerulopathies.Complement C1 esterase inhibitor levels linked to infections and contaminated heparin-associated adverse eventsCharacterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor.Defining the complement biomarker profile of C3 glomerulopathyDense deposit disease.Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopyRare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activityRegulating complement in the kidney: insights from CFHR5 nephropathy.Association of a novel complement factor H mutation with severe crescentic and necrotizing glomerulonephritis.Eculizumab and recurrent C3 glomerulonephritisSecondary focal and segmental glomerulosclerosis associated with single-nucleotide polymorphisms in the genes encoding complement factor H and C3.Treatment options for C3 glomerulopathyCauses of alternative pathway dysregulation in dense deposit disease.A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor HGlomerulonephritis with isolated C3 deposits and monoclonal gammopathy: a fortuitous association?Complement Dysregulation and Disease: Insights from Contemporary Genetics.The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient miceManipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.New classification of membranoproliferative glomerulonephritis: a good start but a long way to go.C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.
P2860
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P2860
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Human C3 mutation reveals a me ...... ent activation and regulation.
@ast
Human C3 mutation reveals a me ...... ent activation and regulation.
@en
Human C3 mutation reveals a me ...... ent activation and regulation.
@nl
type
label
Human C3 mutation reveals a me ...... ent activation and regulation.
@ast
Human C3 mutation reveals a me ...... ent activation and regulation.
@en
Human C3 mutation reveals a me ...... ent activation and regulation.
@nl
prefLabel
Human C3 mutation reveals a me ...... ent activation and regulation.
@ast
Human C3 mutation reveals a me ...... ent activation and regulation.
@en
Human C3 mutation reveals a me ...... ent activation and regulation.
@nl
P2093
P2860
P356
P1476
Human C3 mutation reveals a me ...... ent activation and regulation.
@en
P2093
Agustín Tortajada
B Paul Morgan
Claire L Harris
Eduardo Vazquez-Martul
Eva Torreira
Francisco Valdes-Cañedo
Margarita Lopez-Trascasa
Meike Heurich
Oscar Llorca
Rubén Martínez-Barricarte
P2860
P304
P356
10.1172/JCI43343
P407
P577
2010-09-13T00:00:00Z