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Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

http://www.wikidata.org/entity/Q34165592

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An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C Acquired hemophilia A: emerging treatment options.Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test - Demonstrated in vitro and ex vivo.Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding.Novel therapeutic approaches for haemophilia.New and Emerging Agents for the Treatment of Hemophilia: Focus on Extended Half-Life Recombinant Clotting Proteins.Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa.

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Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

http://www.wikidata.org/entity/Q34165592

description

2014 nî lūn-bûn

@nan

2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

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2014年論文

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2014年论文

@wuu

name

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

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Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@en

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@nl

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label

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@ast

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@en

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@nl

prefLabel

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@ast

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@en

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@nl

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P1433

Journal of Thrombosis and Haemostasis

P1476

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

@en

P2093

A J Gale

http://www.w3.org/2001/XMLSchema#string

A von Drygalski

http://www.w3.org/2001/XMLSchema#string

L O Mosnier

http://www.w3.org/2001/XMLSchema#string

T J Cramer

http://www.w3.org/2001/XMLSchema#string

V Bhat

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis

The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability

The contribution of bovine Factor V and Factor Va to the activity of prothrombinase

Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

Factor V Leiden improves in vivo hemostasis in murine hemophilia models.

Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII.

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment.

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.

Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice.

The regulation of the factor VII-dependent coagulation pathway: rationale for the effectiveness of recombinant factor VIIa in refractory bleeding disorders.

P304

363-372

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scholarly article

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10.1111/JTH.12489

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3

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12

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24818532

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4161283

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