Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase.
about
Computer aided enzyme design and catalytic conceptsEngineering a model protein cavity to catalyze the Kemp eliminationIterative approach to computational enzyme designPrecision is essential for efficient catalysis in an evolved Kemp eliminasePerspective: Defining and quantifying the role of dynamics in enzyme catalysisMultiscale Modeling of Biological Functions: From Enzymes to Molecular Machines (Nobel Lecture)Computational protein engineering: bridging the gap between rational design and laboratory evolution.Achievements and Challenges in Computational Protein Design.Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: a comparison to analogous phosphatases.Large shifts in pKa values of lysine residues buried inside a protein.Challenges and advances in validating enzyme design proposals: the case of kemp eliminase catalysisOptZyme: computational enzyme redesign using transition state analoguesConverting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome.Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.Dissecting enzyme function with microfluidic-based deep mutational scanningValidating the vitality strategy for fighting drug resistance.Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes.Computational strategies for the design of new enzymatic functionsUse of an Improved Matching Algorithm to Select Scaffolds for Enzyme Design Based on a Complex Active Site ModelCADEE: Computer-Aided Directed Evolution of Enzymes.Process considerations for the asymmetric synthesis of chiral amines using transaminases.Emerging themes in the computational design of novel enzymes and protein-protein interfaces.Computational enzyme design.Computational design gains momentum in enzyme catalysis engineering.Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges.Multi-scale computational enzymology: enhancing our understanding of enzymatic catalysis.Computational Enzyme Design: Advances, hurdles and possible ways forwardRecent advances in rational approaches for enzyme engineering.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.The role of side chain entropy and mutual information for improving the de novo design of Kemp eliminases KE07 and KE70.The linear interaction energy method for the prediction of protein stability changes upon mutationHyperconjugation-mediated solvent effects in phosphoanhydride bonds.Electrostatic origin of the catalytic effect of a supramolecular host catalyst.Modeling catalytic promiscuity in the alkaline phosphatase superfamily.Substrate selectivity of high-activity mutants of human butyrylcholinesterase.Simulating the catalytic effect of a designed mononuclear zinc metalloenzyme that catalyzes the hydrolysis of phosphate triesters.Computational design of a Diels-Alderase from a thermophilic esterase: the importance of dynamics.Systematic optimization model and algorithm for binding sequence selection in computational enzyme design.Exploring the Development of Ground-State Destabilization and Transition-State Stabilization in Two Directed Evolution Paths of Kemp Eliminases.
P2860
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P2860
Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Exploring challenges in ration ...... in artificial kemp eliminase.
@ast
Exploring challenges in ration ...... in artificial kemp eliminase.
@en
Exploring challenges in ration ...... in artificial kemp eliminase.
@nl
type
label
Exploring challenges in ration ...... in artificial kemp eliminase.
@ast
Exploring challenges in ration ...... in artificial kemp eliminase.
@en
Exploring challenges in ration ...... in artificial kemp eliminase.
@nl
prefLabel
Exploring challenges in ration ...... in artificial kemp eliminase.
@ast
Exploring challenges in ration ...... in artificial kemp eliminase.
@en
Exploring challenges in ration ...... in artificial kemp eliminase.
@nl
P2093
P2860
P356
P1476
Exploring challenges in ration ...... in artificial kemp eliminase.
@en
P2093
Maria P Frushicheva
Zhen T Chu
P2860
P304
16869-16874
P356
10.1073/PNAS.1010381107
P407
P577
2010-09-09T00:00:00Z