Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling - Wikidata - wikimedia - TriplyDB

Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling

Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling

http://www.wikidata.org/entity/Q34170848

about

Circadian regulation of metabolic homeostasis: causes and consequences Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health Transcriptional regulation of hepatic lipogenesis Impact of the circadian clock on the aging process Evolving roles of circadian rhythms in liver homeostasis and pathology Circadian Influence on Metabolism and Inflammation in Atherosclerosis.Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice.Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes.Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock Δ19/+ mice contributes to improved glucose homeostasis Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.CREBH Couples Circadian Clock With Hepatic Lipid Metabolism.CLOCK-BMAL1 regulate the cardiac L-type calcium channel subunit CACNA1C through PI3K-Akt signaling pathway.Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model.Circadian rhythms in mitochondrial respiration.An individual 12-h shift of the light-dark cycle alters the pancreatic and duodenal circadian rhythm and digestive function.The satiety factor oleoylethanolamide impacts hepatic lipid and glucose metabolism in goldfish.

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Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling

http://www.wikidata.org/entity/Q34170848

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@ast

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@en

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@nl

type

label

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@ast

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@en

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@nl

prefLabel

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@ast

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@en

Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@nl

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JBC.M114.567628

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Journal of Biological Chemistry

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Liver clock protein BMAL1 prom ...... h insulin-mTORC2-AKT signaling

@en

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Avani Kamath

http://www.w3.org/2001/XMLSchema#string

Blake Arthurs

http://www.w3.org/2001/XMLSchema#string

Deqiang Zhang

http://www.w3.org/2001/XMLSchema#string

Ken Inoki

http://www.w3.org/2001/XMLSchema#string

Lei Yin

http://www.w3.org/2001/XMLSchema#string

Liangyou Rui

http://www.w3.org/2001/XMLSchema#string

Xin Tong

http://www.w3.org/2001/XMLSchema#string

P2860

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Insulin signalling and the regulation of glucose and lipid metabolism

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

Obesity and metabolic syndrome in circadian Clock mutant mice

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

A genome-wide RNAi screen for modifiers of the circadian clock in human cells

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25925-25935

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10.1074/JBC.M114.567628

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37

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2014-07-25T00:00:00Z

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