Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay. - Wikidata - wikimedia - TriplyDB

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.

http://www.wikidata.org/entity/Q34174445

about

What does our genome encode?Defining functional DNA elements in the human genome Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome Decoding the non-coding genome: elucidating genetic risk outside the coding genome Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS Massively parallel sequencing: the new frontier of hematologic genomics A new era for functional labeling of neurons: activity-dependent promoters have come of age Synthetic biology in mammalian cells: next generation research tools and therapeutics From trans to cis: transcriptional regulatory networks in neocortical development Functional anatomy of distant-acting mammalian enhancers Advanced Applications of RNA Sequencing and Challenges Homotypic clusters of transcription factor binding sites: A model system for understanding the physical mechanics of gene expression Enhancer scanning to locate regulatory regions in genomic loci Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations DNA-dependent formation of transcription factor pairs alters their binding specificity Decoding enhancers using massively parallel reporter assays Towards structural systems pharmacology to study complex diseases and personalized medicine Can a few non-coding mutations make a human brain?BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Many human accelerated regions are developmental enhancers Massively parallel cis-regulatory analysis in the mammalian central nervous system Discrimination between thermodynamic models of cis-regulation using transcription factor occupancy data.Parametric inference in the large data limit using maximally informative models.Incorporating chromatin accessibility data into sequence-to-expression modeling TagGD: fast and accurate software for DNA Tag generation and demultiplexing Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior The jigsaw puzzle of sequence phenotype inference: Piecing together Shannon entropy, importance sampling, and Empirical Bayes.A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells Function-based identification of mammalian enhancers using site-specific integration.pBACode: a random-barcode-based high-throughput approach for BAC paired-end sequencing and physical clone mapping Transversions have larger regulatory effects than transitions.Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features.Non-Coding Loss-of-Function Variation in Human Genomes.PPARγ and the global map of adipogenesis and beyond.An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval.Genome-wide quantitative enhancer activity maps identified by STARR-seq.Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters.High-throughput functional testing of ENCODE segmentation predictions.

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P2860

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.

http://www.wikidata.org/entity/Q34174445

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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Systematic dissection and opti ...... ively parallel reporter assay.

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Systematic dissection and opti ...... ively parallel reporter assay.

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Systematic dissection and opti ...... ively parallel reporter assay.

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Nature Biotechnology

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Systematic dissection and opti ...... ively parallel reporter assay.

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P2093

Alexandre Melnikov

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Anand Murugan

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Andreas Gnirke

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Curtis G Callan

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Li Wang

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Peter Rogov

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Soheil Feizi

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Tarjei S Mikkelsen

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Xiaolan Zhang

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Construction and model-based analysis of a promoter library for E. coli: an indispensable tool for metabolic engineering

Initial impact of the sequencing of the human genome

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation

High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing

An Atomic Model of the Interferon-β Enhanceosome

Transcriptional regulation by the phosphorylation-dependent factor CREB

The NIH Roadmap Epigenomics Mapping Consortium

Bioluminescent assays for high-throughput screening.

Synthetic design of strong promoters

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271-277

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10.1038/NBT.2137

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3

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30

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Justin B Kinney

Tiberiu Tesileanu

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2012-02-26T00:00:00Z

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221867259

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1004566758

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22371084

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3297981

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