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The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeA safe lithium mimetic for bipolar disorderEvidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusibComputational Approaches for the Discovery of Human Proteasome Inhibitors: An OverviewKynurenine Aminotransferase Isozyme Inhibitors: A ReviewRedox-dependent regulation of epidermal growth factor receptor signalingMolecular docking and structure-based drug design strategiesTen things you should know about protein kinases: IUPHAR Review 14Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesThe pharmacological landscape and therapeutic potential of serine hydrolasesDeveloping irreversible inhibitors of the protein kinase cysteinomeOn the Mechanism of Dimethylarginine Dimethylaminohydrolase Inactivation by 4-HalopyridinesStructural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interactionMechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosisPiperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside MacrophagesAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateReversible targeting of noncatalytic cysteines with chemically tuned electrophilesStructure-Based Design of Covalent Siah InhibitorsEvaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural ApproachesStilbene Vinyl Sulfonamides as Fluorogenic Sensors of and Traceless Covalent Kinetic Stabilizers of Transthyretin That Prevent AmyloidogenesisIn situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12CTargeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitmentInsight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFRIdentification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidaseRedox-dependent anti-inflammatory signaling actions of unsaturated fatty acidsCombined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas' diseaseDiscovery of host-targeted covalent inhibitors of dengue virusMetabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible InhibitorsThe Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision MakingOptical control of endogenous receptors and cellular excitability using targeted covalent photoswitchesSynthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer CellsCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsDevelopment of methods for the bioanalysis of RRx-001 and metabolites.Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scaleTargeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryReactive intermediates: molecular and MS-based approaches to assess the functional significance of chemical-protein adducts.High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform.Substituted tetrazoles as multipurpose screening compounds.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The resurgence of covalent drugs.
@ast
The resurgence of covalent drugs.
@en
The resurgence of covalent drugs.
@nl
type
label
The resurgence of covalent drugs.
@ast
The resurgence of covalent drugs.
@en
The resurgence of covalent drugs.
@nl
prefLabel
The resurgence of covalent drugs.
@ast
The resurgence of covalent drugs.
@en
The resurgence of covalent drugs.
@nl
P2093
P356
P1476
The resurgence of covalent drugs.
@en
P2093
Adrian Whitty
Juswinder Singh
Russell C Petter
Thomas A Baillie
P2888
P304
P356
10.1038/NRD3410
P577
2011-04-01T00:00:00Z