Very few substitutions in a germ line antibody are required to initiate significant domain exchange.
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Antibody promiscuity: Understanding the paradigm shift in antigen recognitionRecent strategies targeting HIV glycans in vaccine designMixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvantsAntibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain ExchangedFocused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep SequencingSomatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationAntibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.A single mutation turns a non-binding germline-like predecessor of broadly neutralizing antibody into a binding antibody to HIV-1 envelope glycoproteins.HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.Structure-based vaccine design in HIV: blind men and the elephant?Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelopeCrystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannosePGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies.Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.Anti-HIV B Cell lines as candidate vaccine biosensors.Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.Antibody recognition of HIV and dengue glycoproteins.Broadly Neutralizing Antibody-Guided Carbohydrate-Based HIV Vaccine Design: Challenges and Opportunities.High temperature SELMA: evolution of DNA-supported oligomannose clusters which are tightly recognized by HIV bnAb 2G12.Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgMPromiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.Conference report: "Functional Glycomics in HIV Type 1 Vaccine Design" workshop report, Bethesda, Maryland, April 30-May 1, 2012.Interrogation of side chain biases for oligomannose recognition by antibody 2G12 via structure-guided phage display libraries.Display of the HIV envelope protein at the yeast cell surface for immunogen development
P2860
Q26801316-4D938E7C-3795-4E2B-815A-49077A167EABQ26823603-11B67A6A-FC3B-495E-A052-AFB7C2A45E0BQ27304735-D7398088-1BC0-4ED8-A8AF-C22159EA7D85Q27664038-75392514-2CB7-4130-AD83-CC2A2E5825E8Q27671696-A10D58FB-9591-4879-BAB8-6CD828C53AEDQ27677117-0B130F48-3EB8-4EDF-A173-8052A8DF1A6BQ34075820-F0E97BB8-DB93-4F7F-A6FD-0400A261A214Q34182218-7E3ABD91-5A05-4A50-AAD4-AD1A2C53DEB0Q34915786-5924E5B6-6804-4C26-848F-75828CD98BABQ34987048-69C5B22D-B9BB-4654-AC34-3331FC9676FDQ34991017-47DE74AE-ECD3-4276-9F33-D171006AD894Q35119778-678F2E54-9E7E-483E-8D7D-B9085DDE6FE8Q35868102-062377B6-5F8C-4AA2-96A7-53F1564085B8Q36607316-2D41BF16-42A6-4FEF-880C-0663114C5B7CQ36693991-B3F36A5F-01F0-4E81-9CD0-5DD10A9CD5E5Q36766704-FA0BEF48-BA40-48C7-A076-3FE2B3CDEB48Q38050485-440B48DB-97E5-4C34-9163-DED3F61685FCQ38293417-5A8CFBFF-1BBB-4CAC-8302-959F9F6C6927Q38695294-4E3AB249-79A6-47D7-A630-E68127D59A56Q38732360-0549D27B-EA53-491D-A3D6-EAE7E46C1B6EQ40679052-505E4FC4-BA03-489C-A48B-D681BF52A07BQ41273804-62B87BDC-B149-40EE-B51C-EDF474B59EC1Q42215329-7DDDA29F-64B5-44C4-80F8-6EE6FE961590Q42933039-C0737843-4D01-40AF-B650-18B667B838D0Q47633687-028BDAAA-81D3-451A-8AA6-D5436539509DQ58601813-CA874E49-8F16-4C0F-ACA3-68969AE962B8
P2860
Very few substitutions in a germ line antibody are required to initiate significant domain exchange.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Very few substitutions in a ge ...... e significant domain exchange.
@ast
Very few substitutions in a ge ...... e significant domain exchange.
@en
Very few substitutions in a ge ...... e significant domain exchange.
@nl
type
label
Very few substitutions in a ge ...... e significant domain exchange.
@ast
Very few substitutions in a ge ...... e significant domain exchange.
@en
Very few substitutions in a ge ...... e significant domain exchange.
@nl
prefLabel
Very few substitutions in a ge ...... e significant domain exchange.
@ast
Very few substitutions in a ge ...... e significant domain exchange.
@en
Very few substitutions in a ge ...... e significant domain exchange.
@nl
P2093
P2860
P356
P1433
P1476
Very few substitutions in a ge ...... te significant domain exchange
@en
P2093
Dennis R Burton
Ian A Wilson
Robyn L Stanfield
Zara Fulton
P2860
P304
10700-10707
P356
10.1128/JVI.01111-10
P407
P577
2010-08-11T00:00:00Z