Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. - Wikidata - wikimedia - TriplyDB

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation.

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation.

http://www.wikidata.org/entity/Q34182097

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Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4).Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4 Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53 Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology.Chemical biology of protein arginine modifications in epigenetic regulation Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions.Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF.Activation of PAD4 in NET formation.Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps Chemical Proteomic Platform To Identify Citrullinated Proteins Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity.Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis Evolution of a mass spectrometry-grade protease with PTM-directed specificity.In vivo relevance of citrullinated proteins and the challenges in their detection.The protein arginine deiminases: Structure, function, inhibition, and disease.Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms.Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis.Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis.PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis.Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis How citrullination invaded rheumatoid arthritis research.The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis.Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen During Antigen-Processing.Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release.Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire.Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis.Presence and role of anti-citrullinated protein antibodies in experimental arthritis models.Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.Human Deiminases: Isoforms, Substrate Specificities, Kinetics, and Detection.Autoantibodies: double agents in human disease.Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features.

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P2860

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation.

http://www.wikidata.org/entity/Q34182097

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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Autocitrullination of human pe ...... nation during cell activation.

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Arthritis & Rheumatology

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Autocitrullination of human pe ...... nation during cell activation.

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Antony Rosen

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Erika Darrah

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Felipe Andrade

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Marjan Gucek

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Robert N Cole

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Xiaoming Zhu

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P2860

Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study

Histone deimination antagonizes arginine methylation

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4

Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes

PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

Structural basis for Ca(2+)-induced activation of human PAD4

Human PAD4 regulates histone arginine methylation levels via demethylimination

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1630-1640

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10.1002/ART.27439

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6

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62

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41722888

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20201080

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2951335

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