about
Mutation of exposed hydrophobic amino acids to arginine to increase protein stabilityEntropic stabilization of proteins and its proteomic consequencesProtein stability: computation, sequence statistics, and new experimental methodsThermophilic proteins: insight and perspective from in silico experimentsAn Integrated Structural and Computational Study of the Thermostability of Two Thioredoxin Mutants from Alicyclobacillus acidocaldariusStructure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stabilityRational stabilization of enzymes by computational redesign of surface charge-charge interactionsA Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature ActivityElectrostatic Contribution of Surface Charge Residues to the Stability of a Thermophilic Protein: Benchmarking Experimental and Predicted pKa ValuesHow oligomerization contributes to the thermostability of an archaeon protein. Protein L-isoaspartyl-O-methyltransferase from Sulfolobus tokodaiiRemoval of surface charge-charge interactions from ubiquitin leaves the protein folded and very stableMutational investigation of protein folding transition states by Phi-value analysis and beyond: lessons from SH3 domain folding.A double-deletion method to quantifying incremental binding energies in proteins from experiment: example of a destabilizing hydrogen bonding pair.Glucosylation of beta-lactoglobulin lowers the heat capacity change of unfolding; a unique way to affect protein thermodynamicsModulation of protein stability and aggregation properties by surface charge engineering.Configurational entropy elucidates the role of salt-bridge networks in protein thermostability.A method to rationally increase protein stability based on the charge-charge interaction, with application to lipase LipK107.Structural and dynamic properties that govern the stability of an engineered fibronectin type III domainDistance dependence and salt sensitivity of pairwise, coulombic interactions in a proteinMechanisms for stabilisation and the maintenance of solubility in proteins from thermophiles.Predicting changes in protein thermostability brought about by single- or multi-site mutationsHydration of the peptide backbone largely defines the thermodynamic propensity scale of residues at the C' position of the C-capping box of alpha-helices.The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric proteinProtonation/deprotonation effects on the stability of the Trp-cage miniprotein.Characterization of the linker 2 region in human vimentin using site-directed spin labeling and electron paramagnetic resonance.Electrostatic contributions to T4 lysozyme stability: solvent-exposed charges versus semi-buried salt bridges.Toward the physical basis of thermophilic proteins: linking of enriched polar interactions and reduced heat capacity of unfolding.Electrostatic contributions to the stability of a thermophilic cold shock protein.Comparison of calculation and experiment implicates significant electrostatic contributions to the binding stability of barnase and barstarModulation of folding energy landscape by charge-charge interactions: linking experiments with computational modelingProtein surface charge of trypsinogen changes its activation pattern.Folding without charges.Carboxyl pK(a) values, ion pairs, hydrogen bonding, and the pH-dependence of folding the hyperthermophile proteins Sac7d and Sso7dComputational design of the Fyn SH3 domain with increased stability through optimization of surface charge charge interactionsElectrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments.Large-scale modulation of thermodynamic protein folding barriers linked to electrostaticsSingle molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins.Calculation of the relative metastabilities of proteins using the CHNOSZ software packageEngineering folding dynamics from two-state to downhill: application to λ-repressor.Lessons about protein stability from in vitro selections.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
To charge or not to charge?
@ast
To charge or not to charge?
@en
To charge or not to charge?
@nl
type
label
To charge or not to charge?
@ast
To charge or not to charge?
@en
To charge or not to charge?
@nl
prefLabel
To charge or not to charge?
@ast
To charge or not to charge?
@en
To charge or not to charge?
@nl
P1476
To charge or not to charge?
@en
P2093
Makhatadze GI
Sanchez-Ruiz JM
P304
P356
10.1016/S0167-7799(00)01548-1
P577
2001-04-01T00:00:00Z