Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. - Wikidata - wikimedia - TriplyDB

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

http://www.wikidata.org/entity/Q34184126

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IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis Regulation of immune cell function and differentiation by the NKG2D receptor Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes Regulation of Bim in Health and Disease Anticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12 Regulating the immune system via IL-15 transpresentation Foxo3a: an integrator of immune dysfunction during HIV infection NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology IL-15 regulates homeostasis and terminal maturation of NKT cells Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development.Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer.Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection.BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs.Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types.Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.Peripheral natural killer cell maturation depends on the transcription factor Aiolos Intracellular osteopontin regulates homeostasis and function of natural killer cells.The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.Roscovitine-induced apoptosis in neutrophils and neutrophil progenitors is regulated by the Bcl-2-family members Bim, Puma, Noxa and Mcl-1 Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy.PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness The aged nonhematopoietic environment impairs natural killer cell maturation and function.The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM)IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.Natural Killer Cell Memory.Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation.Development and maturation of natural killer cells The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.FoxO1-mediated autophagy is required for NK cell development and innate immunity.Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155

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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

http://www.wikidata.org/entity/Q34184126

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2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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Edwina Naik

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Grant Dewson

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Hyacinth Tabarias

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Mariapia A Degli-Esposti

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Nicholas D Huntington

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Noboru Motoyama

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Priscilla Gunn

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Simon N Willis

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Bim: a novel member of the Bcl-2 family that promotes apoptosis

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

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856-863

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10.1038/NI1487

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8

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8

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Andreas Strasser

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Hamsa Puthalakath

David M Tarlinton

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2007-07-08T00:00:00Z

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232784570

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17618288

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