HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses

HIV controllers with HLA-DRB113 and HLA-DQB106 alleles have strong, polyfunctional mucosal CD4+ T-cell responses

http://www.wikidata.org/entity/Q34190681

Q34190681

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Genetically modified hematopoietic stem cell transplantation for HIV-1-infected patients: can we achieve a cure?A DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responses The role of common protective alleles HLA-DRB1*13 among systemic autoimmune diseases.Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?Induction of Potent and Long-Lived Antibody and Cellular Immune Responses in the Genitorectal Mucosa Could be the Critical Determinant of HIV Vaccine Efficacy.Regulation of HIV-Gag expression and targeting to the endolysosomal/secretory pathway by the luminal domain of lysosomal-associated membrane protein (LAMP-1) enhance Gag-specific immune response.Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic Controllers Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy Mucosal immunity in human and simian immunodeficiency lentivirus infections Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller Characterization of HIV-specific CD4+ T cell responses against peptides selected with broad population and pathogen coverage.Evaluating cellular polyfunctionality with a novel polyfunctionality index.Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides.A small set of succinct signature patterns distinguishes Chinese and non-Chinese HIV-1 genomes.Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues.Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity.Characterization of an effective CTL response against HIV and SIV infections.Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.In vitro sensitization of T cells with DC-associated/delivered HIV constructs can induce a polyfunctional CTL response, memory T-cell response, and virus suppression Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers.HIV Envelope Trimer Specific Immune Response Is Influenced by Different Adjuvant Formulations and Heterologous Prime-Boost.Thirty Years with HIV Infection-Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors.The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases.Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses.Conservation of HIV-1 T cell epitopes across time and clades: validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs.Robust immunity to an auxotrophic Mycobacterium bovis BCG-VLP prime-boost HIV vaccine candidate in a nonhuman primate model.Public T cell receptors confer high-avidity CD4 responses to HIV controllers A Recombinant Adenovirus Encoding Multiple HIV-1 Epitopes Induces Stronger CD4(+) T cell Responses than a DNA Vaccine in Mice.Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.Dendritic Cell Targeting Effectively Boosts T Cell Responses Elicited by an HIV Multiepitope DNA Vaccine.Mucosal immunity in HIV controllers: the right place at the right time.HIV-specific CD4 T cells and immune control of viral replication.HIV controllers: a multifactorial phenotype of spontaneous viral suppression.Long-Term Non-Progression and Broad HIV-1-Specific Proliferative T-Cell Responses.HIV controllers: a genetically determined or inducible phenotype?Unravelling the mechanisms of durable control of HIV-1.

P2860

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P2860

HIV controllers with HLA-DRB113 and HLA-DQB106 alleles have strong, polyfunctional mucosal CD4+ T-cell responses

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http://www.wikidata.org/entity/Q34190681

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2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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