Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions.

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions.

Item
http://www.wikidata.org/entity/Q34190909
Different interaction profiles of direct-acting anti-hepatitis C virus agents with human organic anion transporting polypeptidesReduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.Ethnic variability in the plasma exposures of OATP1B1 substrates such as HMG-CoA reductase inhibitors: a kinetic consideration of its mechanism.Prediction of drug disposition on the basis of its chemical structure.Experimental models for predicting drug absorption and metabolism.Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.Dealing with the complex drug-drug interactions: towards mechanistic models.BDDCS, the Rule of 5 and drugability.Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts.Predictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen.High prevalence of potential drug-drug interactions in patients with castration-resistant prostate cancer treated with abiraterone acetate.Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins.Mechanism-based pharmacokinetic modeling to evaluate transporter-enzyme interplay in drug interactions and pharmacogenetics of glyburide.Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.
P2860

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions.

Item
http://www.wikidata.org/entity/Q34190909
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Predicting human hepatic clear ...... essing drug-drug interactions.
@ast
Predicting human hepatic clear ...... essing drug-drug interactions.
@en
Predicting human hepatic clear ...... essing drug-drug interactions.
@nl
type
label
Predicting human hepatic clear ...... essing drug-drug interactions.
@ast
Predicting human hepatic clear ...... essing drug-drug interactions.
@en
Predicting human hepatic clear ...... essing drug-drug interactions.
@nl
prefLabel
Predicting human hepatic clear ...... essing drug-drug interactions.
@ast
Predicting human hepatic clear ...... essing drug-drug interactions.
@en
Predicting human hepatic clear ...... essing drug-drug interactions.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P356
P1433
P1476
Predicting human hepatic clear ...... essing drug-drug interactions.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698