FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions - Wikidata - wikimedia - TriplyDB

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

http://www.wikidata.org/entity/Q34197717

about

Melanoma: oncogenic drivers and the immune system The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides.Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis.Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors Intratumoral convergence of the TCR repertoires of effector and Foxp3+ CD4+ T cells.Hepatic gene transfer as a means of tolerance induction to transgene products Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired Malignant B cells induce the conversion of CD4+CD25- T cells to regulatory T cells in B-cell non-Hodgkin lymphoma Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Analysis of FoxP3+ T-regulatory cells and CD8+ T-cells in ovarian carcinoma: location and tumor infiltration patterns are key prognostic markers.Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer Roles of the immune system in skin cancer.Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression.Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression.Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity.The numbers of FoxP3+ lymphocytes in sentinel lymph nodes of breast cancer patients correlate with primary tumor size but not nodal status Exploiting the curative potential of adoptive T-cell therapy for cancer.Skin-resident T cells: the ups and downs of on site immunity.Influence of human immune cells on cancer: studies at the University of Colorado.The suppressive tumor microenvironment: a challenge in cancer immunotherapy.Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?Melanoma vaccines: developments over the past 10 years.Variation of tumor-infiltrating lymphocytes in human cancers: controversy on clinical significance.Antigen-specific versus antigen-nonspecific immunotherapeutic approaches for human melanoma: the need for integration for optimal efficacy?Developing dendritic cell-based therapies to condition immune responses to novel oncogenic proteins and stem cells.Dermal mast cells affect the development of sunlight-induced skin tumours.Immune alterations in malignant melanoma and current immunotherapy concepts.Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer.Mogamulizumab and the treatment of CCR4-positive T-cell lymphomas.Silencing of Foxp3 delays the growth of murine melanomas and modifies the tumor immunosuppressive environment.Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.Skin Immunity.Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.

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FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

http://www.wikidata.org/entity/Q34197717

description

2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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FOXP3 expression accurately de ...... in metastatic melanoma lesions

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FOXP3 expression accurately de ...... in metastatic melanoma lesions

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FOXP3 expression accurately de ...... in metastatic melanoma lesions

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FOXP3 expression accurately de ...... in metastatic melanoma lesions

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FOXP3 expression accurately de ...... in metastatic melanoma lesions

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FOXP3 expression accurately de ...... in metastatic melanoma lesions

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Aloisio Felipe-Silva

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Bianca Heemskerk

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Daniel J Powell

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John R Wunderlich

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Maria J Merino

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Mojgan Ahmadzadeh

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Steven A Rosenberg

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P2860

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

Control of regulatory T cell development by the transcription factor Foxp3

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

An essential role for Scurfin in CD4+CD25+ T regulatory cells

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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18820132

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