about
The Dawn of Aurora Kinase Research: From Fly Genetics to the ClinicFunctions of Aurora kinase C in meiosis and cancerPrognosis and management of acute myeloid leukemia in patients with Down syndromeCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.A Cell Biologist's Field Guide to Aurora Kinase InhibitorsTranscriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic SignalingAllosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platformPhase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.Altered CELF1 binding to target transcripts in malignant T cells.Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.Phosphorylation of MAP65-1 by Arabidopsis Aurora Kinases Is Required for Efficient Cell Cycle Progression.Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle.Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases.A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivationAURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients.The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.Quinazoline derivatives as anticancer drugs: a patent review (2011 - present).A phase 1 study of AMG 900, an orally administered pan-aurora kinase inhibitor, in adult patients with acute myeloid leukemia.An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Molecular insight into the regulation and function of MCAK.Phosphorylation of Serine 148 in Giardia lamblia End-binding 1 Protein is Important for Cell Division.Clinical Development of Anti-mitotic Drugs in Cancer.Immunotherapy and Targeted Therapy for Small Cell Lung Cancer: There Is Hope.Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral.A SILAC-based proteomics elicits the molecular interactome of alisertib (MLN8237) in human erythroleukemia K562 cells.In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases.Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A.Identification of 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cellsA small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells.A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP.The therapeutic potential of cell cycle targeting in multiple myeloma.
P2860
Q26774424-61AF4AEC-D99A-488E-9013-28253F7BFA2BQ26782717-670C3E70-B236-41DF-9612-0F089C043DA4Q27016577-2D9B80A3-DF17-48A0-B2B8-848954CF729CQ27306356-6219FBCE-9706-4072-B928-BF1875B7CBC1Q27308125-C85F423E-BA9F-418C-875E-AD48AA0FF945Q27853347-939252E3-E3C8-40F0-9708-20D47B1A3A08Q28551996-5D4AB534-65C4-4407-9670-1922D0E20338Q28829011-B155D2A6-A73B-4631-8FB5-0AC7A6AB02FDQ30252352-23B95D1E-C877-4FE6-9CB3-A42733D1758FQ30388525-3B4E4D01-BDDD-41E7-9E14-668C9EFF5C31Q30855089-8CEDC6CF-4812-473A-8BF0-D9AEC93CC53FQ33437992-D2CDE089-94D5-4B99-8A85-574EF7B90AF0Q33781657-BF6119B6-02EE-43BC-9A74-481E9CD7BC5CQ35220665-F42453DF-A0AA-49E7-9DB0-2F84D826D895Q36072305-C9D06845-9D7D-495E-AED7-5BD59AFAD0FFQ36106621-10516E3A-BA15-4EE8-AE51-7F2C3E98D6A6Q36202264-C07DA6AE-9A89-490B-976F-C253CB14E221Q36355904-11E9E61F-9A6C-4A35-8582-2B5BEAE3312DQ36359558-272070BC-B7F2-41C4-AAC1-B8F747EFD217Q37442586-FF343D3F-6CF7-4532-83B4-89259CE76EE3Q37514967-1323AB77-5352-4B6A-9251-9C07789E55B5Q37588080-23022B8E-1100-4F7F-96AB-D9162A95B9CCQ37709004-AABAE2BD-B686-40CE-AD89-144E6503B2AFQ38262590-B6A9A08A-ECF7-46A5-94C0-158612EB3117Q38298911-80F3EFAF-E50B-448C-AEE4-A841A4461074Q38440766-8DA9E7F5-165A-4562-BD89-BCF71EADA449Q38735991-133A17FD-8FA7-4139-9FB3-E4960EBB412BQ38783162-635168CF-4849-4D48-9DCA-6120A68676DCQ38825915-D6F7017C-0B29-45A6-988B-5B610B366B66Q39136619-D202E920-84BE-436F-B8ED-1E7C131749B6Q39363642-20E8C302-3F4C-4882-9FEB-59E061CFAC17Q39393217-BC044E74-CD94-465A-BD84-0EE5DFD28758Q40051127-7F6E9290-7C9E-4C72-86D6-A0867828E9FAQ40065746-CE32C544-240E-4684-B7D4-46A9F97830F5Q40997106-8291DD14-60D8-498C-AC1A-CF8D768C7032Q42046251-04D81F0A-F6EF-4207-832A-5C761BC63C40Q42132814-F099A136-5E54-453E-BCAD-23A5E6EE07EFQ42378370-A3BEBA40-3F8D-42E5-990E-A7BEDFDE5913Q46011991-61A1D748-69BB-4B9D-AA8A-C1866D583C45Q47203904-C182BA1F-DF88-471A-87DE-A3ABB2004DC4
P2860
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
The aurora kinases in cell cycle and leukemia
@ast
The aurora kinases in cell cycle and leukemia
@en
The aurora kinases in cell cycle and leukemia
@nl
type
label
The aurora kinases in cell cycle and leukemia
@ast
The aurora kinases in cell cycle and leukemia
@en
The aurora kinases in cell cycle and leukemia
@nl
prefLabel
The aurora kinases in cell cycle and leukemia
@ast
The aurora kinases in cell cycle and leukemia
@en
The aurora kinases in cell cycle and leukemia
@nl
P2860
P921
P356
P1433
P1476
The aurora kinases in cell cycle and leukemia
@en
P2093
B Goldenson
P2860
P2888
P304
P356
10.1038/ONC.2014.14
P407
P577
2014-03-17T00:00:00Z
P5875
P6179
1020726947