The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.
about
Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifenSynthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19PharmGKB summary: tamoxifen pathway, pharmacokineticsInhibition of cytochrome p450 enzymes by the e- and z-isomers of norendoxifen.Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activitiesPersonalized medicine and cancer.Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer.Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development.Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen-treated Asian breast cancer patients.Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.Tamoxifen in the Mouse Brain: Implications for Fate-Mapping Studies Using the Tamoxifen-Inducible Cre-loxP System.Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells.A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.The Cytochrome P450 Enzyme Responsible for the Production of (Z)-Norendoxifen in vitro.
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P2860
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@ast
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@en
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase
@nl
type
label
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@ast
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@en
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase
@nl
prefLabel
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@ast
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@en
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase
@nl
P2093
P2860
P1476
The tamoxifen metabolite noren ...... for novel therapeutic agents.
@en
P2093
Abdelrahman S Mayhoub
Mark Cushman
Wenjie Jessie Lu
P2860
P2888
P304
P356
10.1007/S10549-011-1699-4
P407
P577
2011-08-04T00:00:00Z
P5875
P6179
1037069419