Small molecule inhibitors of DNA repair nuclease activities of APE1.
about
Base excision repair and cancerAag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1Double threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine-thymine mismatchDiverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionNucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsTargeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.Targeting DNA repair pathways for cancer treatment: what's new?Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionInhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesNew Frontiers in DruggabilityBase excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsSmall molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neuronsAn APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypesRepair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomideBalancing repair and tolerance of DNA damage caused by alkylating agentsEvidence for base excision repair processing of DNA interstrand crosslinks.Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic SitesSynthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer.Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repairHuman apurinic/apyrimidinic endonuclease 1.SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.New oligonucleotide derivatives as unreactive substrate analogues and potential inhibitors of human apurinic/apyrimidinic endonuclease APE1.RKIP-mediated chemo-immunosensitization of resistant cancer cells via disruption of the NF-κB/Snail/YY1/RKIP resistance-driver loopNanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation.Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.Down-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) in spinal motor neurones under oxidative stress.Construction of a Full-Atomic Mechanistic Model of Human Apurinic/Apyrimidinic Endonuclease APE1 for Virtual Screening of Novel Inhibitors.Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell SurvivalBase excision DNA repair and cancer.Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma.Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking.
P2860
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P2860
Small molecule inhibitors of DNA repair nuclease activities of APE1.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@ast
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@en
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@nl
type
label
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@ast
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@en
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@nl
prefLabel
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@ast
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@en
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@nl
P2860
P1476
Small molecule inhibitors of DNA repair nuclease activities of APE1.
@en
P2093
David M Wilson
P2860
P2888
P304
P356
10.1007/S00018-010-0488-2
P577
2010-08-31T00:00:00Z