Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. - Wikidata - wikimedia - TriplyDB

Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

http://www.wikidata.org/entity/Q34211312

about

The Ubiquitination of NF-κB Subunits in the Control of Transcription Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions The paracaspase MALT1: biological function and potential for therapeutic inhibition Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase MALT1 is not alone after all: identification of novel paracaspases The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells The CBM signalosome: potential therapeutic target for aggressive lymphoma?Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.Mechanism and specificity of the human paracaspase MALT1.The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.Frequent engagement of RelB activation is critical for cell survival in multiple myeloma.Protein ubiquitination in lymphoid malignancies.Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression.MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications.Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling.Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage.The Paracaspase MALT1.The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.A new look at T cell receptor signaling to nuclear factor-κB Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies.MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation.A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma.MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo Regulation of NF-κB by deubiquitinases.

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Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

http://www.wikidata.org/entity/Q34211312

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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type

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Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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prefLabel

Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

@en

Malt1-dependent RelB cleavage ...... cytes and lymphoma cell lines.

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PNAS.1105020108

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Proceedings of the National Academy of Sciences of the United States of America

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Malt1-dependent RelB cleavage ...... ocytes and lymphoma cell lines

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Bernd Dörken

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Chantal Décaillet

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Christiane Pelzer

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Georg Lenz

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Hendrik Nogai

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Jean-Enno Charton

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Katrin Cabalzar

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Maike Jaworski

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Montserrat Guzzardi

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Peter Lenz

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P2860

I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif

NF-kappaB regulation in the immune system

Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase

Phosphorylation of CARMA1: the link(er) to NF-kappaB activation

Regulation and function of NF-kappaB transcription factors in the immune system

A loss-of-function RNA interference screen for molecular targets in cancer.

RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts.

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14596-14601

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108

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