Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production - Wikidata - wikimedia - TriplyDB

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

http://www.wikidata.org/entity/Q34212784

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Keeping mtDNA in shape between generations Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease Mitochondrial aging and age-related dysfunction of mitochondria SOD2 deficiency promotes aging phenotypes in mouse skin Mitochondrial involvement and impact in aging skeletal muscle Mitochondrial proteostasis in the control of aging and longevity Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity Strong purifying selection in transmission of mammalian mitochondrial DNA Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress Patterns of positive selection in seven ant genomes Aging and the Mammalian regulatory triumvirate Evolutionary patterns of the mitochondrial genome in Metazoa: exploring the role of mutation and selection in mitochondrial protein coding genes Correlates of substitution rate variation in mammalian protein-coding sequences Recognition and control of the progression of age-related hearing loss.Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease Stochastic drift in mitochondrial DNA point mutations: a novel perspective ex silico The role of mitochondrial DNA mutations in mammalian aging Mitigating mutational meltdown in mammalian mitochondria.Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration.Mitochondrial function as a determinant of life span.New insights on NOX enzymes in the central nervous system.The road to rack and ruin: selecting deleterious mitochondrial DNA variants Chronic ethanol consumption increases myocardial mitochondrial DNA mutations: a potential contribution by mitochondrial topoisomerases Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect.Mitochondrial genome maintenance in health and disease.Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.Mitochondrial DNA repair and association with aging--an update Taking a "good" look at free radicals in the aging process.Role of somatic mutations in vascular disease formation.A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts.

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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

http://www.wikidata.org/entity/Q34212784

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2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Somatic mtDNA mutations cause ...... tive oxygen species production

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Proceedings of the National Academy of Sciences of the United States of America

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Somatic mtDNA mutations cause ...... tive oxygen species production

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P2093

Aleksandra Trifunovic

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Anja T Rovio

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Anna Hansson

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Anna Wredenberg

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Eric Dufour

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Howard T Jacobs

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Ivan Khvorostov

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Johannes N Spelbrink

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Rolf Wibom

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P2860

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

Aging: a theory based on free radical and radiation chemistry

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

The biologic clock: the mitochondria?

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

Mitochondrial disease in superoxide dismutase 2 mutant mice

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

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