Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.
about
B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycanThe glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylationSGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan functionO-Mannosylation and human diseaseA Method to Produce and Purify Full-Length Recombinant Alpha Dystroglycan: Analysis of N- and O-Linked Monosaccharide Composition in CHO Cells with or without LARGE OverexpressionAGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycanLARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophyThe Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary DystroglycanopathyXylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2The Dystrophin Complex: Structure, Function, and Implications for TherapyStructural basis of laminin binding to the LARGE glycans on dystroglycan.The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan additionHigh throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin bindingProbing the stability of the "naked" mucin-like domain of human α-dystroglycanDownregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma.Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases.The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer.Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephalyLoss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.Milder forms of muscular dystrophy associated with POMGNT2 mutations.Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathySparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogsMining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans.Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: α-dystroglycan and forms of muscular dystrophy.Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates.Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.What Have We Learned from Glycosyltransferase Knockouts in Mice?Structure-function relationship of the mammarenavirus envelope glycoprotein.Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes.Recent advancements in understanding mammalian O-mannosylation.Structural flexibility of human α-dystroglycan.The evolution of the dystroglycan complex, a major mediator of muscle integrity.Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin.The genomic landscape of African populations in health and disease.Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.Defects in glycosylation impair satellite stem cell function and niche composition in the muscles of the dystrophic Large(myd) mouse.Direct Mapping of Additional Modifications on Phosphorylated O-glycans of α-Dystroglycan by Mass Spectrometry Analysis in Conjunction with Knocking Out of Causative Genes for Dystroglycanopathy.Lectin-binding characterizes the healthy human skeletal muscle glycophenotype and identifies disease-specific changes in dystrophic muscle.
P2860
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P2860
Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Like-acetylglucosaminyltransfe ...... ding and arenavirus infection.
@ast
Like-acetylglucosaminyltransfe ...... ding and arenavirus infection.
@en
Like-acetylglucosaminyltransferase
@nl
type
label
Like-acetylglucosaminyltransfe ...... ding and arenavirus infection.
@ast
Like-acetylglucosaminyltransfe ...... ding and arenavirus infection.
@en
Like-acetylglucosaminyltransferase
@nl
prefLabel
Like-acetylglucosaminyltransfe ...... ding and arenavirus infection.
@ast
Like-acetylglucosaminyltransfe ...... ding and arenavirus infection.
@en
Like-acetylglucosaminyltransferase
@nl
P2093
P2860
P356
P1476
Like-acetylglucosaminyltransfe ...... nding and arenavirus infection
@en
P2093
Jakob S Satz
Michael B A Oldstone
Motoi Kanagawa
Steven J Burden
Takako Yoshida-Moriguchi
Yvonne M Kobayashi
P2860
P304
17426-17431
P356
10.1073/PNAS.1114836108
P407
P577
2011-10-10T00:00:00Z