Fluorine local environment: from screening to drug design.
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Applications of (19)F-NMR in Fragment-Based Drug DiscoveryA Protein Data Bank survey reveals shortening of intermolecular hydrogen bonds in ligand-protein complexes when a halogenated ligand is an H-bond donorHarnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue DrugsSynthetic biology approaches to fluorinated polyketidesWeak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH.Design and generation of highly diverse fluorinated fragment libraries and their efficient screening with improved (19) F NMR methodology.Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γFragment-based drug discovery as alternative strategy to the drug development for neglected diseases.Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cellsFluorinated carbohydrates as lectin ligands: dissecting glycan-cyanovirin interactions by using 19F NMR spectroscopy.Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2.Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions.Forbidden Coherence Transfer of 19F Nuclei to Quantitatively Measure the Dynamics of a CF₃-Containing Ligand in Receptor-Bound States.Current NMR Techniques for Structure-Based Drug Discovery.Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds.19 F NMR isotropic chemical shift for efficient screening of fluorinated fragments which are racemates and/or display multiple conformers.Novel Potent and Selective Acetylcholinesterase Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease: Synthesis, Pharmacological Evaluation, and Molecular Modeling of Amino-Alkyl-Substituted Fluoro-Chalcones Derivatives.The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands.Fluorinated amino acids in amyloid formation: a symphony of size, hydrophobicity and α-helix propensity(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillationPractical Methods for the Synthesis of Trifluoromethylated Alkynes: Oxidative Trifluoromethylation of Copper Acetylides and Alkynes
P2860
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P2860
Fluorine local environment: from screening to drug design.
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Fluorine local environment: from screening to drug design.
@ast
Fluorine local environment: from screening to drug design.
@en
Fluorine local environment: from screening to drug design.
@nl
type
label
Fluorine local environment: from screening to drug design.
@ast
Fluorine local environment: from screening to drug design.
@en
Fluorine local environment: from screening to drug design.
@nl
prefLabel
Fluorine local environment: from screening to drug design.
@ast
Fluorine local environment: from screening to drug design.
@en
Fluorine local environment: from screening to drug design.
@nl
P1433
P1476
Fluorine local environment: from screening to drug design.
@en
P2093
Anna Vulpetti
Claudio Dalvit
P304
P356
10.1016/J.DRUDIS.2012.03.014
P577
2012-04-03T00:00:00Z