Characterization of a human peptide deformylase: implications for antibacterial drug design.
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An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayHuman mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsStructure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer TargetUnderstanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpartSolvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase.Inhibition of human peptide deformylase disrupts mitochondrial functionOverexpression of peptide deformylase in breast, colon, and lung cancers.Peptide deformylase inhibitors as potent antimycobacterial agents.Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.Therapeutic potential of peptide deformylase inhibitors.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin.New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor.Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activityCrystallization and preliminary X-ray crystallographic analysis of peptide deformylase (PDF) from Bacillus cereus in ligand-free and actinonin-bound forms.Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase.Expression, purification, and activity assay of peptide deformylase from Escherichia coli and Staphylococcus aureus.Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.An improved crystal form of Plasmodium falciparum peptide deformylaseProteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus.Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases.Type 3 peptide deformylases are required for oxidative phosphorylation in Trypanosoma brucei.Isolation and identification of FR198248, a hydroxylated 1,3-dihydroisobenzofuran, from Aspergillus flavipes as an inhibitor of peptide deformylase.Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis.
P2860
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P2860
Characterization of a human peptide deformylase: implications for antibacterial drug design.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Characterization of a human pe ...... for antibacterial drug design.
@ast
Characterization of a human pe ...... for antibacterial drug design.
@en
Characterization of a human pe ...... for antibacterial drug design.
@nl
type
label
Characterization of a human pe ...... for antibacterial drug design.
@ast
Characterization of a human pe ...... for antibacterial drug design.
@en
Characterization of a human pe ...... for antibacterial drug design.
@nl
prefLabel
Characterization of a human pe ...... for antibacterial drug design.
@ast
Characterization of a human pe ...... for antibacterial drug design.
@en
Characterization of a human pe ...... for antibacterial drug design.
@nl
P2093
P356
P1433
P1476
Characterization of a human pe ...... for antibacterial drug design.
@en
P2093
Craig Colton
Kiet T Nguyen
Michael X Zhu
Ratna Chakrabarti
P304
P356
10.1021/BI0346446
P407
P577
2003-08-01T00:00:00Z