N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.
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Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in ratsSyntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptorsCharacterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptorsTrans-activation between 7TM domains: implication in heterodimeric GABAB receptor activationPositive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models.Structure and ligand recognition of class C GPCRsDiscovery of a Negative Allosteric Modulator of GABAB ReceptorsSleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression.GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorThe GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat.Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaineCGP7930: a positive allosteric modulator of the GABAB receptor.Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats.Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in ratsEvaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile.A Gut Feeling about GABA: Focus on GABA(B) Receptors.Allosteric modulation of the M₃ muscarinic receptor by amiodarone and N-ethylamiodarone: application of the four-ligand allosteric two-state model.GABAB receptor upregulates fragile X mental retardation protein expression in neuronsEffects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryPositive allosteric modulation of the GABA(B) receptor by GS39783 attenuates the locomotor stimulant actions of ethanol and potentiates the induction of locomotor sensitization.Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.Anxiety-like behaviors at the end of the nocturnal period in sP rats with a "history" of unpredictable, limited access to alcoholLigand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission.Targeting opioid receptor heterodimers: strategies for screening and drug developmentDiscriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.Mechanism-based medication development for the treatment of nicotine dependence.Alterations in the rate of binge ethanol consumption: implications for preclinical studies in mice.Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity.Novel GABA(B) receptor positive modulators: a patent survey.Efficacy and tolerability of baclofen in substance use disorders: a systematic review.GABA pharmacology: the search for analgesics.KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats.Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors.Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1.
P2860
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P2860
N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
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name
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@ast
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@en
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@nl
type
label
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@ast
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@en
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@nl
prefLabel
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@ast
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@en
N,N'-Dicyclopentyl-2-methylsul ...... tyric acidB receptor function.
@nl
P2093
P356
P1476
N,N'-Dicyclopentyl-2-methylsul ...... utyric acidB receptor function
@en
P2093
Christina Lampert
Johannes Mosbacher
Kurt Lingenhoehl
Manuel Koller
Mario F Pozza
Stephan Urwyler
Wolfgang Froestl
P304
P356
10.1124/JPET.103.053074
P407
P50
P577
2003-09-03T00:00:00Z