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Quantifying factors for the success of stratified medicine.

Quantifying factors for the success of stratified medicine.

http://www.wikidata.org/entity/Q34228544

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Technologies for deriving primary tumor cells for use in personalized cancer therapy The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development.Clustering of longitudinal data by using an extended baseline: A new method for treatment efficacy clustering in longitudinal data.Can 'humanized' mice improve drug development in the 21st century?From molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action.Aligning the economic value of companion diagnostics and stratified medicines.Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population Pharmacogenomics of preterm birth prevention and treatment.A Quantitative Assessment of Factors Affecting the Technological Development and Adoption of Companion Diagnostics PIPELINEs: Creating Comparable Clinical Knowledge Efficiently by Linking Trial Platforms.Therapeutic target database update 2014: a resource for targeted therapeutics.Patenting personalized medicines in the UK, Europe and USA.Individualizing prophylaxis in hemophilia: a review.The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.Toward Precision Healthcare: Context and Mathematical Challenges Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells.Towards a balanced value business model for personalized medicine: an outlook.Clinical trial simulation to assist in COPD trial planning and design with a biomarker-based diagnostic: when to pull the trigger?Encapsulated Optically Responsive Cell Systems: Toward Smart Implants in Biomedicine.Anticancer drug development from traditional cytotoxic to targeted therapies: evidence of shorter drug research and development time, and shorter drug lag in Japan.Relationships of Ex-Vivo Drug Resistance Assay and Cytokine Production with Clinicopathological Features in the Primary Cell Culture of Thai Ovarian and Fallopian Tube Cancer Patients Molecular biomarkers in clinical development: what could we learn from the clinical trial registry?[Personalised medicine. Aims and challenges].Stratified medicine: a call for action

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Quantifying factors for the success of stratified medicine.

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Quantifying factors for the success of stratified medicine.

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Nature Reviews Drug Discovery

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Quantifying factors for the success of stratified medicine.

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Abhijit Mazumder

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Aiden A Flynn

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Alfons Lieftucht

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Breon Burgess

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David Swank

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Ernst R Berndt

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Federico Goodsaid

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Jian Wang

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Judy Milloy

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Mark R Trusheim

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

The Path to Personalized Medicine

BRAF mutation predicts sensitivity to MEK inhibition

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817-833

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10.1038/NRD3557

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11

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10

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