P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
about
Melanoma: from melanocyte to genetic alterations and clinical optionsExome sequencing identifies recurrent somatic RAC1 mutations in melanomaIntravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progressionRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseThe melanocyte lineage in development and diseaseNorbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loopsSynaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behaviorP-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironmentsRegulation and function of P-Rex family Rac-GEFsCRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growthNovel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivoP-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site.Efficient gene expression profiling of laser-microdissected melanoma metastases.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.Classifying ten types of major cancers based on reverse phase protein array profiles.Human melanoma metastasis in NSG mice correlates with clinical outcome in patients.RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics.The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.Identification of metastasis-suppressive microRNAs in primary melanomaChromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells.The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALINGThe transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation.The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast CancersProteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors.Deregulation of Rho GTPases in cancerCharacterization of a P-Rex1 gene signature in breast cancer cellsPREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion.Emerging molecular targets in melanoma invasion and metastasis.Cellular and molecular mechanisms controlling the migration of melanocytes and melanoma cells.Melanoma metastasis: new concepts and evolving paradigms.The biology of melanocyte and melanocyte stem cell.
P2860
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P2860
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@ast
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@en
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@nl
type
label
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@ast
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@en
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@nl
prefLabel
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@ast
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@en
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@nl
P2093
P2860
P50
P356
P1476
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
@en
P2093
Alexander J Finn
Andrew D Campbell
Brad W Ozanne
Brendan Doyle
Channing Der
Colin R Lindsay
Craig Carson
Enda W McDermott
Florian Rambow
P2860
P2888
P356
10.1038/NCOMMS1560
P50
P577
2011-11-22T00:00:00Z
P5875
P6179
1040317174