Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility
about
Accurate Determination of Conformational Transitions in Oligomeric Membrane Proteins.Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatasePropensity to form amyloid fibrils is encoded as excitations in the free energy landscape of monomeric proteins.AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures.Differential effects of glycation on protein aggregation and amyloid formation.Implications of protein structure instability: from physiological to pathological secondary structure.Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation.Structural dynamics and conformational equilibria of SERCA regulatory proteins in membranes by solid-state NMR restrained simulations.Intrinsic disorder modulates protein self-assembly and aggregation.The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments.Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organismsComparing the energy landscapes for native folding and aggregation of PrP.Thermodynamic characterization of the unfolding of the prion protein.Bacterial cell division regulation by Ser/Thr kinases: a structural perspectiveMisfolding of amyloidogenic proteins and their interactions with membranes.Conformational recognition of an intrinsically disordered protein.Substrate dynamics in enzyme action: rotations of monosaccharide subunits in the binding groove are essential for pectin methylesterase processivity.Energy landscape of the prion protein helix 1 probed by metadynamics and NMR.Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.Understanding the effect of alternative splicing in the folding and function of the second PDZ from protein tyrosine phosphatase-BL.Characterizing intermolecular interactions that initiate native-like protein aggregation.Delicate balance between functionally required flexibility and aggregation risk in a β-rich protein.Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations.Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.Water is an active matrix of life for cell and molecular biology.Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies.The structural basis of nanobody unfolding reversibility and thermoresistance.Signature of Pareto optimization in the Escherichia coli proteome.
P2860
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P2860
Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Experimental free energy surfa ...... ntenance of protein solubility
@ast
Experimental free energy surfa ...... ntenance of protein solubility
@en
Experimental free energy surfa ...... ntenance of protein solubility
@nl
type
label
Experimental free energy surfa ...... ntenance of protein solubility
@ast
Experimental free energy surfa ...... ntenance of protein solubility
@en
Experimental free energy surfa ...... ntenance of protein solubility
@nl
prefLabel
Experimental free energy surfa ...... ntenance of protein solubility
@ast
Experimental free energy surfa ...... ntenance of protein solubility
@en
Experimental free energy surfa ...... ntenance of protein solubility
@nl
P2093
P2860
P50
P356
P1476
Experimental free energy surfa ...... ntenance of protein solubility
@en
P2093
Alfonso De Simone
Anne Dhulesia
Fabrizio Chiti
Gemma Soldi
P2860
P304
21057-21062
P356
10.1073/PNAS.1112197108
P407
P577
2011-12-12T00:00:00Z