Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
about
A Pan-GTPase Inhibitor as a Molecular ProbeDedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulationEssential role of Elmo1 in Dock2-dependent lymphocyte migrationCrystal structure of ethyl 2-({[(4Z)-3,5-dioxo-1-phenyl-pyrazolidin-4-yl-idene]meth-yl}amino)-acetate.Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectivesDedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formationRac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells.The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.Design of small molecules that compete with nucleotide binding to an engineered oncogenic KRAS allele.The Rac Activator DOCK2 Mediates Plasma Cell Differentiation and IgG Antibody Production.SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines.DOCK2 is critical for CD8(+) TCR(-) graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells.Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model.
P2860
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P2860
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@ast
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@en
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@nl
type
label
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@ast
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@en
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@nl
prefLabel
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@ast
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@en
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@nl
P2093
P50
P1476
Blockade of inflammatory respo ...... or of the Rac activator DOCK2.
@en
P2093
Atsushi Suenaga
Fumiyuki Sanematsu
Hideki Sumimoto
Kei Miyano
Motomu Kanai
Qinhong Cao
Shunsuke Sakaoka
Takashi Saitoh
Takayoshi Okabe
P304
P356
10.1016/J.CHEMBIOL.2012.03.008
P50
P577
2012-04-01T00:00:00Z