Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus.
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Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane.Establishment of monoclonal anti-retroviral gp70 autoantibodies from MRL/lpr lupus mice and induction of glomerular gp70 deposition and pathology by transfer into non-autoimmune mice.Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequencesCD8+ Tregs in lupus, autoimmunity, and beyond.Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides.Modulation of autoimmunity with artificial peptidesInterferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice.The molecular biology of anti-DNA antibodies and their idiotopes.Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.Modulation of murine systemic lupus erythematosus with peptides based on complementarity determining regions of a pathogenic anti-DNA monoclonal antibody.Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype.Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupusNucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupusSubsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines.Isolated VH4 heavy chain variable regions bind DNA characterization of a recombinant antibody heavy chain library derived from patient(s) with active SLE.Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone miceLigand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity.Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus.Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.Thermodynamic analysis of monoclonal antibody binding to duplex DNA.Idiotype manipulation for autoimmune diseases: where are we going?Generation, characterization, and docking studies of DNA-hydrolyzing recombinant F(ab) antibodies.Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptide.Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systemic lupus erythematosus: relation of cytokine pattern to disease duration.Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice.Self Ig peptides: key players in sustaining autoimmunity to dsDNA.The role of VL gene structural determinants in the fine specificity of anti-DNA antibodies.
P2860
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P2860
Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus.
description
1990 nî lūn-bûn
@nan
1990 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Structural characteristics of ...... autoantibody in murine lupus.
@ast
Structural characteristics of ...... autoantibody in murine lupus.
@en
Structural characteristics of ...... autoantibody in murine lupus.
@nl
type
label
Structural characteristics of ...... autoantibody in murine lupus.
@ast
Structural characteristics of ...... autoantibody in murine lupus.
@en
Structural characteristics of ...... autoantibody in murine lupus.
@nl
prefLabel
Structural characteristics of ...... autoantibody in murine lupus.
@ast
Structural characteristics of ...... autoantibody in murine lupus.
@en
Structural characteristics of ...... autoantibody in murine lupus.
@nl
P2093
P2860
P356
P1476
Structural characteristics of ...... autoantibody in murine lupus.
@en
P2093
F M Ebling
N Panosian-Sahakian
P2860
P304
P356
10.1172/JCI114469
P407
P577
1990-02-01T00:00:00Z