Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel. - Wikidata - wikimedia - TriplyDB

Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel.

Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel.

http://www.wikidata.org/entity/Q34251031

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The role of TRPMLs in endolysosomal trafficking and function Permeation, regulation and control of expression of TRP channels by trace metal ions Regulation of lysosomal ion homeostasis by channels and transporters Mucolipidosis type IV: an update Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1 X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder.Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity.Lysosomal physiology.Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway Zinc-permeable ion channels: effects on intracellular zinc dynamics and potential physiological/pathophysiological significance.TRPML: transporters of metals in lysosomes essential for cell survival?Regulation of TRPML1 function.Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis.Transition metals activate TFEB in overexpressing cells The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter Mobilization of stored iron in mammals: a review.Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.Lysosomal metal, redox and proton cycles influencing the CysHis cathepsin reaction.Contribution of calcium-conducting channels to the transport of zinc ions.The biology of zinc transport in mammary epithelial cells: implications for mammary gland development, lactation, and involution.The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.ROS and intracellular ion channels.Mucolipidosis type IV protein TRPML1-dependent lysosome formation.PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene.A novel role of transient receptor potential mucolipin1 (TRPML1) in protecting against imidazole-induced cytotoxicity.The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling.Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?Genetics of the human face: Identification of large-effect single gene variants.Dysregulation of autophagy as a common mechanism in lysosomal storage diseases.Novel degenerative and developmental defects in a zebrafish model of mucolipidosis type IV.The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM.Superiority of SpiroZin2 Versus FluoZin-3 for monitoring vesicular Zn allows tracking of lysosomal Zn pools

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P2860

Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel.

http://www.wikidata.org/entity/Q34251031

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

@ast

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

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Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

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type

label

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

@ast

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

@en

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

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prefLabel

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

@ast

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

@en

Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

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JBC.C110.165480

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Journal of Biological Chemistry

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Zinc dyshomeostasis is linked ...... associated TRPML1 ion channel.

@en

P2093

Jeffrey A Evans

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Jonathan L Eichelsdoerfer

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Math P Cuajungco

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Susan A Slaugenhaupt

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P2860

Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells.

Small molecule activators of TRPML3

Modulation of mitochondrial function by endogenous Zn2+ pools.

The neurobiology of zinc in health and disease.

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.

Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis

Autophagic dysfunction in mucolipidosis type IV patients.

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