Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. - Wikidata - wikimedia - TriplyDB

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

http://www.wikidata.org/entity/Q34253805

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Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification Chinese Herbal Medicine-induced Liver Injury Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase A genomic and evolutionary approach reveals non-genetic drug resistance in malaria Plasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial Cells A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function.Indoleamine 2,3 dioxygenase and metabolic control of immune responses.Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice.Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors.Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans.Evolutionary molecular medicine.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy.Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.Discovery of Dual-Stage Malaria Inhibitors with New Targets.Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases.The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Therapeutic interventions to disrupt the protein synthetic machinery in melanoma Aminoacyl-tRNA synthetases in medicine and disease Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone.Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival.Hypoxia and Mucosal Inflammation.

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P2860

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

http://www.wikidata.org/entity/Q34253805

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@ast

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@en

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@nl

type

label

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@ast

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@en

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@nl

prefLabel

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@ast

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

@en

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

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Nature Chemical Biology

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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

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Anjana Rao

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Davide Zocco

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Hak-Kyo Lee

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Jinah Yum

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John David Dignam

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Joseph F Cortese

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Maja Edenius

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Malcolm Whitman

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Margaret Hendrick

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Mark S Sundrud

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P2860

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Extending healthy life span--from yeast to humans

mTOR: from growth signal integration to cancer, diabetes and ageing

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase

Regulated translation initiation controls stress-induced gene expression in mammalian cells

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

Regulation of immune responses by L-arginine metabolism

Aminoacyl-tRNA synthesis

S100A4 and metastasis: a small actor playing many roles

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311-317

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10.1038/NCHEMBIO.790

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3

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8

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Ralph Mazitschek

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2012-02-12T00:00:00Z

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221825834

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22327401

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3281520

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