Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production
about
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexinsThe specific α-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse developmentFE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowthCalsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transportThe Kinesin Adaptor Calsyntenin-1 Organizes Microtubule Polarity and Regulates Dynamics during Sensory Axon Arbor Development.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionCalsyntenin-1 regulates axon branching and endosomal trafficking during sensory neuron development in vivo.Calsyntenin-3 molecular architecture and interaction with neurexin 1α.Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanismsAutophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex.Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.Elevated O-GlcNAcylation of Extracellular Vesicle Proteins Derived from Metastatic Colorectal Cancer Cells.Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.Axonal transport defects in Alzheimer's disease.Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E.Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid.Calsyntenins Are Expressed in a Dynamic and Partially Overlapping Manner during Neural Development.Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.Zebrafish calsyntenins mediate homophilic adhesion through their amino-terminal cadherin repeats.Altered expression of neurofilament 200 and amyloid-β peptide (1-40) in a rat model of chronic cerebral hypoperfusion.Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans.Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Investigation of the Subcellular Neurotoxicity of Amyloid-β Using a Device Integrating Microfluidic Perfusion and Chemotactic Guidance.Regulation of Glutamate Signaling in the Sensorimotor Circuit by CASY-1A/Calsyntenin in Caenorhabditis elegans.Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease.Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration.The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction.Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain
P2860
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P2860
Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@ast
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@en
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@nl
type
label
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@ast
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@en
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@nl
prefLabel
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@ast
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@en
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@nl
P2093
P2860
P356
P1476
Calsyntenin-1 mediates axonal ...... in and regulates Aβ production
@en
P2093
Alessio Vagnoni
Christopher C J Miller
Emma H Gray
Michael S Perkinton
P2860
P304
P356
10.1093/HMG/DDS109
P577
2012-03-20T00:00:00Z