The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
about
Rational and combinatorial tailoring of bioactive cyclic dipeptidesThe unexpected evolution of basic science studies about cyclic nucleotide action into a treatment for erectile dysfunction.Virtual screening and drug design for PDE-5 receptor from traditional Chinese medicine database.Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Transition-metal-catalyzed C-H bond functionalizations: feasible access to a diversity-oriented β-carboline library.Rh(II)2-catalyzed synthesis of α-, β-, or δ-carbolines from aryl azides.Biofocussed chemoprospecting: An efficient approach for drug discovery.Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of MeiosisSynthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.Role of phosphodiesterase 5 in synaptic plasticity and memoryStructure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives.Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.Isolation and structural characterization of a new tadalafil analog (2-hydroxyethylnortadalafil) found in a dietary supplement.Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.Enantioselective synthesis of tryptophan derivatives by a tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction.Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme.Key features for designing phosphodiesterase-5 inhibitors.The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.Tadalafil and vardenafil.The direct amidation of α-diketones with amines via TBHP-promoted oxidative cleavage of C(sp(2))-C(sp(2)) bonds.Vardenafil ameliorates immunologic- and non-immunologic-induced allergic reactions.Identification of a new tadalafil analogue found in a dietary supplement.JNJ-10280205 and JNJ-10287069: Novel PDE5 inhibitors as clinical candidates for erectile dysfunction.Phosphodiesterase type 5 and cancers: progress and challenges.Nickel(II)-assisted enantiomeric differentiation and quantitation of tadalafil by direct electrospray ionization mass spectrometry.Doubly charged trimeric cluster ions: effective in mutual chiral recognition of tadalafil and three proton pump inhibitors.Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product.Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil.Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions.Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifsSynthesis and Evaluation of Antiplasmodial Efficacy of β-Carboline Derivatives against Murine Malaria
P2860
Q26797349-ABA3137F-22FA-4416-894A-94E3C9EEF5C2Q30361487-0EF412A8-AFDF-473A-8058-52898476F86AQ33525137-9CCF221C-ECDF-4C22-8577-EAE08785FC30Q34538482-71EEA573-82BF-4910-BB65-6ECB19F41702Q35093418-C7593448-780B-4F4D-985C-528A91181469Q36098141-BE297DFC-1053-4F19-9762-C2450B5487F6Q36264598-0FA2FDF1-EB57-46A5-95B6-3807B872AF96Q36689825-84E797B1-9891-473D-BD17-1BDBF6C4ED85Q37082085-162E8C54-5F39-468F-9362-A8C712FC86C8Q37167091-17E58BD0-ED10-4D6A-803E-662BB7F27D76Q37252748-25B748F4-0DA1-46ED-97AE-C73555B7C80CQ37339495-C9AA9A16-F8EB-4FEA-826D-B1C18BE6E492Q37636142-3BF961D7-1943-448B-B2F2-CDD6D832C8C5Q41383381-E5650BFA-C775-4016-B9B9-790AF5F3818BQ41740635-FDEEE17F-A361-4A4E-8256-A03C8D6EB0EBQ41889474-EBD7EF46-AA1B-414F-943B-C9632E830DEAQ42096089-A60C587A-AF63-4B51-8078-689D6C47230EQ42364583-62F501A5-088A-4ED1-9962-CE8CE0DA34D9Q42581981-C5223FEA-0513-41F7-9A3D-FF93F55B5E80Q42870680-A9002BEF-70DE-4D8A-9D09-62902E20A527Q43203048-CA47F18A-BE45-45F2-9734-778D6C9AC934Q43908604-8A18FCFD-95DB-49DC-B430-CF3492364681Q44102856-B75CB50A-E078-43DB-A561-B5F6F6C69A5EQ44297447-A39A63D4-D3DA-4BAC-BFE5-0AD3C39FCFDCQ46973877-D734FF08-2672-4605-A4C9-BFD443DB5BD4Q46983898-74CFE7BD-B6B2-4F13-A65D-6DE7153A1310Q47171803-763623C4-8D68-479F-867D-D72AE5ED2AAEQ48062290-D6439E6E-620D-4D0D-B85F-760A92BE5F1FQ48237136-23272E1F-1596-4D13-B593-296295A4C365Q51157253-56D5457D-AF01-44FB-8710-64B7197EA5C6Q53301815-544EA806-7274-44AC-98BA-BDBE198DA74DQ54374606-7D5E86BE-2A98-4E32-8069-6E41CF1EB016Q55345179-5C21A8B6-9DB7-4665-A605-E36FFA8A3D1EQ57834025-89B50181-8C50-4451-82A2-E22BF0371F66Q58581156-2EA306DE-D0B3-4687-8298-C6148162D739
P2860
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@ast
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@en
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@nl
type
label
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@ast
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@en
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@nl
prefLabel
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@ast
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@en
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@nl
P2093
P356
P1476
The discovery of tadalafil: a ...... -b]indole-1,4-dione analogues.
@en
P2093
Alain Daugan
Anne-Charlotte Le Monnier de Gouville
Cécile Ruault
François Hyafil
Hervé Coste
Jean Michel Linget
Jorge Kirilovsky
Pascal Grondin
P304
P356
10.1021/JM0300577
P407
P577
2003-10-01T00:00:00Z