Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. - Wikidata - wikimedia - TriplyDB

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

http://www.wikidata.org/entity/Q34266771

about

The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)Chemogenomics: an emerging strategy for rapid target and drug discovery Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4 Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner Deubiquitinases (DUBs) and DUB inhibitors: a patent review Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo [Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157].Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans Deubiquitinating enzymes as promising drug targets for infectious diseases.Cloning and molecular characterization of delta12-fatty acid desaturase gene from Mortierella isabellina.A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.Emerging principles in protease-based drug discovery.Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.Development of inhibitors in the ubiquitination cascade.Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis.Ubiquitin carboxyl terminal hydrolyase L1-suppressed autophagic degradation of p21WAF1/Cip1 as a novel feedback mechanism in the control of cardiac fibroblast proliferation Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.A three-stage kinetic model of amyloid fibrillation.Age-related proteomic changes in the subventricular zone and their association with neural stem/progenitor cell proliferation.Ubiquitin C-terminal hydrolase l1 in tumorigenesis Engagement of ubiquitination and de-ubiquitination at rostral ventrolateral medulla in experimental brain death.Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa.Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes.UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14 Reverse the curse--the role of deubiquitination in cell cycle control.Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.Strategies for the identification of novel inhibitors of deubiquitinating enzymes.Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs.Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.Emerging therapies targeting the ubiquitin proteasome system in cancer The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics The enzymes in ubiquitin-like post-translational modifications.

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P2860

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

http://www.wikidata.org/entity/Q34266771

description

2003 nî lūn-bûn

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2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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type

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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Discovery of inhibitors that e ...... e H1299 lung cancer cell line.

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J.CHEMBIOL.2003.08.010

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Chemistry and Biology

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April Case

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Gregory D Cuny

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Jake Ni

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Li-An Yeh

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Peter T Lansbury

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Ross L Stein

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Sungwoon Choi

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Xuechao Xing

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Yichin Liu

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837-846

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scholarly article

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