2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo - Wikidata - wikimedia - TriplyDB

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo

http://www.wikidata.org/entity/Q34270459

about

A Mouse Model of Zika Virus Pathogenesis Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional West Nile Virus Infection in the Central Nervous System Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant New insights into innate immune restriction of West Nile virus infection To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes A viral RNA structural element alters host recognition of nonself RNA The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5 Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses A complement-microglial axis drives synapse loss during virus-induced memory impairment.Predicted structure and domain organization of rotavirus capping enzyme and innate immune antagonist VP3 Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals.Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.Interferon-induced Ifit proteins: their role in viral pathogenesis Structure-based identification of functional residues in the nucleoside-2'-O-methylase domain of Bluetongue virus VP4 capping enzyme.IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon Identification and expression analysis of the interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) gene in duck (Anas platyrhynchos domesticus).Mechanisms of innate immune evasion in re-emerging RNA viruses.Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families.Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA.Cell-intrinsic innate immune control of West Nile virus infection.Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs.Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid.A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes A death-promoting role for ISG54/IFIT2 A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response.A role for Ifit2 in restricting West Nile virus infection in the brain Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression.IFIT1 polymorphisms predict interferon-α treatment efficiency for hepatitis B virus infection.Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.IFITs: Emerging Roles as Key Anti-Viral Proteins

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P2860

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo

http://www.wikidata.org/entity/Q34270459

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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Brian P Daniels

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Ganes C Sen

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Hyelim Cho

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Maria D Gainey

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Robyn S Klein

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Wayne M Yokoyama

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P2860

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs

Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1

The interferon stimulated gene 54 promotes apoptosis

ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response

Characterization of the interaction between the interferon-induced protein P56 and the Int6 protein encoded by a locus of insertion of the mouse mammary tumor virus.

Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

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e1002698

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10.1371/JOURNAL.PPAT.1002698

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5

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8

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Michael S. Diamond

Herbert W. "Skip" Virgin

Kristy J Szretter

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2012-05-10T00:00:00Z

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224966926

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22589727

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West Nile virus

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3349756

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