Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway.
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ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key PlayersNon-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transitionSilencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening.Overexpression of the Na+/H+ exchanger and ischemia-reperfusion injury in the myocardium.Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemiaBrain-on-a-chip microsystem for investigating traumatic brain injury: Axon diameter and mitochondrial membrane changes play a significant role in axonal response to strain injuries.The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cellsExcessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemiaCritical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation - the rat isolated working heart.Intracellular Acid-extruding regulators and the effect of lipopolysaccharide in cultured human renal artery smooth muscle cells.Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated heartsInhibition of Na⁺-H⁺ exchange as a mechanism of rapid cardioprotection by resveratrol.Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion.Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood.miR-185 inhibits endoplasmic reticulum stress-induced apoptosis by targeting Na+/H+ exchanger-1 in the heart.Regulation of cell survival by Na+/H+ exchanger-1.Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial functionUnique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury.O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death.Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress.Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris.Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis.Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I.Cariporide sensitizes leukemic cells to tumor necrosis factor related apoptosis-inducing ligand by up-regulation of death receptor 5 via endoplasmic reticulum stress-CCAAT/enhancer binding protein homologous protein dependent mechanism.Mitochondrial NHE1: a newly identified target to prevent heart disease.Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes.Rapid pacing of embryoid bodies impairs mitochondrial ATP synthesis by a calcium-dependent mechanism--a model of in vitro differentiated cardiomyocytes to study molecular effects of tachycardia.Biochemical and Molecular Alterations Following Arsenic-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain.Stimulation of astrocyte Na+/H+ exchange activity in response to in vitro ischemia depends in part on activation of ERK1/2.Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries.Na+/Ca2+ exchanger plays a key role in inducing apoptosis after hypoxia in cultured guinea pig ventricular myocytes.Protective effects of cariporide on endothelial dysfunction induced by high glucose.Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model.Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart.Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action.Protection of ischaemic-reperfused rat heart by dimethylamiloride is associated with inhibition of mitochondrial permeability transition.Cardiomyokines from the heart.Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition.The Na+/H+ exchanger-1 inhibitor cariporide prevents glutamate-induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload.Cariporide enables hemodynamically more effective chest compression by leftward shift of its flow-depth relationship.
P2860
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P2860
Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@ast
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@en
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@nl
type
label
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@ast
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@en
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@nl
prefLabel
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@ast
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@en
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@nl
P2093
P1433
P1476
Cariporide (HOE642), a selecti ...... e mitochondrial death pathway.
@en
P2093
Eduardo Marbán
Masaharu Akao
Steven P Jones
Yasushi Teshima
P304
P356
10.1161/01.CIR.0000093277.20968.C7
P407
P577
2003-10-20T00:00:00Z