Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
about
Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's diseaseTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Translatability scoring in drug development: eight case studiesA mutation in APP protects against Alzheimer’s disease and age-related cognitive declineAspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's diseaseThe novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complexAssociation of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor proteinLysophosphatidylcholine modulates fibril formation of amyloid beta peptideGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionTransforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor proteinFlotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sortingLysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin SPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationNicalin and its binding partner Nomo are novel Nodal signaling antagonistsThe presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residueProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesHuman aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor proteinInteraction of presenilins with the filamin family of actin-binding proteinsBACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinGleevec inhibits beta-amyloid production but not Notch cleavagePro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHEpigenetic Alterations in Alzheimer's DiseaseThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationDementia of the eye: the role of amyloid beta in retinal degenerationAlzheimer's therapeutics: translation of preclinical science to clinical drug developmentThe relevance of beta-amyloid on markers of Alzheimer's disease in clinically normal individuals and factors that influence these associationsBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer's diseaseGenetic heterogeneity in Alzheimer disease and implications for treatment strategiesGenetic of Alzheimer's Disease: A Narrative Review ArticleThe anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complexInterictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathologyDoes neuroinflammation fan the flame in neurodegenerative diseases?The struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseCurrent and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysThree dimensions of the amyloid hypothesis: time, space and 'wingmen'The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine depositsβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease
P2860
Q21132276-AFF2C135-4BD6-478B-BADA-D218FB0D5EDDQ21202832-7CB26D0B-52CF-45B1-BF29-F1D256202D4BQ22000600-88B49A7C-7A3F-4631-9BCE-0A3F447AAD65Q22241760-890B044E-BC41-4F53-AF50-929022B02BD8Q22251083-DC7FABA1-4F0E-4FB8-BD2F-364CABEF638DQ24203739-AA8EBF48-8728-4277-BD69-4B7119A8D648Q24298756-C78E3418-12AA-4355-A0A7-F2B513C77092Q24303383-B6E4E953-6D6C-46FE-A346-C4B29CBECC01Q24312931-E49AA8AF-ADEF-45D6-B25B-2E3DB78FD84AQ24323259-F77D1CDD-FE72-4843-A0BC-D2D05B9AF352Q24336029-806518D1-5C58-4BA2-92C4-E13DF7FFCFA9Q24338342-FDFB9C3E-5C0A-435C-A10D-B51FD7702202Q24338925-3A234871-22ED-4EC2-B3FA-17CC75ADFB07Q24528220-E34C5131-E2C8-4056-B874-7CEB4240ABC1Q24530721-1520C5AC-7242-4E1D-B735-A5EAF16BD495Q24563200-1C40319A-15D7-4FBC-9AC9-214D08D49C0EQ24564792-72124E38-0EB8-4EE7-B8FF-DFA4BCCBC3CEQ24650014-E99797AA-7883-4BDE-BA0C-2B203065A7A1Q24650599-52F03B22-33F9-4572-AB4D-EB7F1F5921B6Q24674595-44FF8039-BAB2-4E73-8EEC-47FF2B81E137Q24675964-9137ACF1-E454-4AD4-BEB8-7E0979036FD1Q24683037-261B8B35-AD7A-420C-A8C0-0D0DD30C364CQ24803627-E094F965-37ED-4822-9D14-086E95B594F9Q26770475-44D616B2-8082-4F22-9534-24352EE8BD04Q26825686-7AECF9F0-3251-4BBD-91EC-BB10FE834E17Q26828978-37BA094D-149D-4681-B049-C770D58D0CF9Q26829267-7D14E2DC-35CF-4421-BBA7-5F88401958EBQ26830467-FE9E2038-309D-4BD2-8941-5D3B1C92F7D0Q26858963-A7EB88E3-A47D-40F5-B243-92E6F79AA2BEQ26992202-51D53DA7-C07E-43ED-B05C-AA6F0294C270Q26995802-FD289500-23B8-440B-A04A-CC4F3E71C4EBQ27007467-04883808-20F4-403E-8FA5-298AF063F64FQ27319458-2B7DBEA5-1CFA-41B9-A6C2-A48E73BE8D69Q27438189-B59A2756-223B-4DF5-B59B-B9AA738CE584Q27498993-F7BE099B-0AC6-4397-A47C-6021B2B68ADEQ28069294-D7E7F940-8DD2-4742-A64B-C167A7B7D94DQ28081678-2A0E81A0-5EF9-44B1-B701-572C180A959DQ28082768-4FC37044-8084-4FC4-998A-E4D535AB5845Q28200789-11B0E359-2954-4C95-9A2E-BCF5E2BB775BQ28245473-03246B57-C141-4B62-BA9F-6E31BD21C295
P2860
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
description
1992 nî lūn-bûn
@nan
1992 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
name
Mutation of the beta-amyloid p ...... eases beta-protein production.
@ast
Mutation of the beta-amyloid p ...... eases beta-protein production.
@en
Mutation of the beta-amyloid p ...... eases beta-protein production.
@nl
type
label
Mutation of the beta-amyloid p ...... eases beta-protein production.
@ast
Mutation of the beta-amyloid p ...... eases beta-protein production.
@en
Mutation of the beta-amyloid p ...... eases beta-protein production.
@nl
prefLabel
Mutation of the beta-amyloid p ...... eases beta-protein production.
@ast
Mutation of the beta-amyloid p ...... eases beta-protein production.
@en
Mutation of the beta-amyloid p ...... eases beta-protein production.
@nl
P2093
P356
P1433
P1476
Mutation of the beta-amyloid p ...... eases beta-protein production.
@en
P2093
Lieberburg I
McConlogue L
Oltersdorf T
Vigo-Pelfrey C
P2888
P304
P356
10.1038/360672A0
P407
P577
1992-12-01T00:00:00Z
P6179
1000102496