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Understanding immunosenescence to improve responses to vaccines

Understanding immunosenescence to improve responses to vaccines

http://www.wikidata.org/entity/Q34281329

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The effect of age on thymic function Avian Influenza Viruses, Inflammation, and CD8(+) T Cell Immunity Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms Modeling Influenza Virus Infection: A Roadmap for Influenza Research Human memory T cells: generation, compartmentalization and homeostasis T-cell aging in rheumatoid arthritis Immunologic changes in frail older adults Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.Pneumococcal Vaccination in High-Risk Individuals: Are We Doing It Right?Primary vaccine failure to routine vaccines: Why and what to do?Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging Paradoxical changes in innate immunity in aging: recent progress and new directions Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults Older Is Not Wiser, Immunologically Speaking: Effect of Aging on Host Response to Clostridium difficile Infections.T cell senescence and cardiovascular diseases.Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of Clostridium difficile Infection.Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses.The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain The future of yogurt: scientific and regulatory needs Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age.Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies Transcriptional signatures of influenza A/H1N1-specific IgG memory-like B cell response in older individuals Pathogen evolution and the immunological niche.Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation.Antiviral B cell and T cell immunity in the lungs.High-dimensional analysis of the aging immune system: verification of age-associated differences in immune signaling responses in healthy donors.Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution A retrospective analysis of the Alzheimer's disease vaccine progress - The critical need for new development strategies.Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase.Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.MicroRNA-125b modulates inflammatory chemokine CCL4 expression in immune cells and its reduction causes CCL4 increase with age.Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults

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Understanding immunosenescence to improve responses to vaccines

http://www.wikidata.org/entity/Q34281329

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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Understanding immunosenescence to improve responses to vaccines

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Understanding immunosenescence to improve responses to vaccines

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Nature Immunology

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Understanding immunosenescence to improve responses to vaccines

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Cornelia M Weyand

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Jörg J Goronzy

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P2860

Vaccines for preventing herpes zoster in older adults

Age-dependent incidence, time course, and consequences of thymic renewal in adults

The PD-1 pathway in tolerance and autoimmunity

Aging of the immune system: how much can the adaptive immune system adapt?

Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation

Changes in primary lymphoid organs with aging

Genetic regulation of thymocyte progenitor aging

Of mice and not men: differences between mouse and human immunology

The influence of age on T cell generation and TCR diversity

miR-181a is an intrinsic modulator of T cell sensitivity and selection

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428-436

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scholarly article

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10.1038/NI.2588

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23598398

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