Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments.
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Glia as drivers of abnormal neuronal activityModulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Ion transporters in brain tumorsEndocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats.The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategiesThe Glutamate-Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation.Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transportersAcute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemiaSeizures and epilepsy: an overview for neuroscientistsThe Subiculum: A Potential Site of Ictogenesis in a Neonatal Seizure Model.Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.Twenty years of fluorescence imaging of intracellular chlorideHow theories evolved concerning the mechanism of action of barbiturates.GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo.Simultaneous optical recording in multiple cells by digital holographic microscopy of chloride current associated to activation of the ligand-gated chloride channel GABA(A) receptor.Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures.Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizuresPre-Clinical Models of Acquired Neonatal Seizures: Differential Effects of Injury on Function of Chloride Co-Transporters.Cation-chloride cotransporters in neuronal development, plasticity and diseasePossible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures.Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivoNKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertensionHomeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporterLimitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport.Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesPentylenetetrazole-induced seizures in developing rats prenatally exposed to valproic acid.Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function.Depolarizing GABA and developmental epilepsies.GABAergic Synchronization in Epilepsy.Exploring the latest avenues for antiepileptic drug discovery and development.Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.Regulating hippocampal hyperexcitability through GABAB Receptors.Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).Chloride co-transporters as possible therapeutic targets for stroke.Furosemide depresses the presynaptic fiber volley and modifies frequency-dependent axonal excitability in rat hippocampus.
P2860
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P2860
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@ast
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@en
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@nl
type
label
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@ast
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@en
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@nl
prefLabel
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@ast
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@en
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@nl
P1433
P1476
Cation-chloride cotransporters ...... antiepileptogenic treatments.
@en
P2093
Martin Puskarjov
Wolfgang Löscher
P356
10.1016/J.NEUROPHARM.2012.05.045
P50
P577
2012-06-15T00:00:00Z